Mouse Gene Set: BIEGING_ROLETT_P53_TUMOR_SUPPRESSION_ASSOCIATED_GENES


Standard name BIEGING_ROLETT_P53_TUMOR_SUPPRESSION_ASSOCIATED_GENES
Systematic name MM19748
Brief description Genes induced by wild-type p53 and by transactivation domain mutants that retain tumor suppressor activity in HRasG12V-expressing MEFs
Full description or abstract Although the p53 transcription factor is a critical tumor suppressor, the molecular pathways through which it acts are incompletely understood. To define the transcriptional programs through which p53 suppresses cancer, we generated a panel of p53 knock-in mouse strains expressing mutants in the first (p53-25,26), second (p53-53,54), or both (p53-25,26,53,54) of two amino-terminal transcriptional activation domains (TADs). We found that p53-25,26 is severely compromised for transactivation of most canonical p53 target genes, but retains the ability to activate a set of primarily novel p53 target genes, while p53-25,26,53,54 lacks transactivation function. The p53-25,26,53,54 mutant is completely defective for tumor suppression, but the p53-25,26 mutant retains full activity in suppressing various cancers. As p53-25,26 activates only a subset of p53-inducible genes, yet retains tumor suppressor activity, it has helped identify a small set of novel, direct p53-inducible tumor suppression-associated target genes (TSAGs) most likely to be important for p53-mediated tumor suppression.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 33157015   Authors: Bieging-Rolett KT,Kaiser AM,Morgens DW,Boutelle AM,Seoane JA,Van Nostrand EL,Zhu C,Houlihan SL,Mello SS,Yee BA,McClendon J,Pierce SE,Winters IP,Wang M,Connolly AJ,Lowe SW,Curtis C,Yeo GW,Winslow MM,Bassik MC,Attardi LD
Exact source Supplemental Table 1. Using microarray data from mouse embryonic fibroblasts (MEFs) expressing oncogenic HrasG12V (Brady et al., 2011), we compared the expression profiles of cells expressing p53 TAD mutants active in tumor suppression (wild-type p53, p53-53,54, and p53-25,26) with expression profiles of cells expressing p53 mutants inactive in tumor suppression (p53-25,26,53,54 and p53 null), and identified genes
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External links https://www.sciencedirect.com/science/article/pii/S1097276520307292?via%3Dihub
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Source species Mus musculus
Contributed by Laura D. Attardi (Stanford University)
Source platform or
identifier namespace		 MOUSE_GENE_SYMBOL
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Version history 2026.1.Mm: First Introduced.


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