Mouse Gene Set: BIOCARTA_D4GDI_PATHWAY

For the Human gene set with the same name, see BIOCARTA_D4GDI_PATHWAY

Standard name BIOCARTA_D4GDI_PATHWAY
Systematic name MM1380
Brief description D4-GDI Signaling Pathway
Full description or abstract D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras related Rho Family of GTPases. Since the rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kDa mature form of D4-GDI to give a 5 kDa and 23 kDa Size fragment. The 23 kDa fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-Terminal kinase, a regulator of apoptosis, may be one of the mechanisms.
Collection M2: Curated
      CP: Canonical Pathways
            CP:BIOCARTA: BioCarta Pathways
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External links https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/mouse/m_d4gdiPathway.gif
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Source species Mus musculus
Contributed by BioCarta
Source platform or
identifier namespace		 MOUSE_SEQ_ACCESSION
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Version history 2022.1.Mm: First Introduced.

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