Mouse Gene Set: BYSTRYKH_SCP2_QTL

For the Human gene set with the same name, see BYSTRYKH_SCP2_QTL

Standard name BYSTRYKH_SCP2_QTL
Systematic name MM1140
Brief description Genes that physically map to the hematopoietic stem cell (HSC) proliferation QTL (quantitative trait locus) Scp2.
Full description or abstract We combined large-scale mRNA expression analysis and gene mapping to identify genes and loci that control hematopoietic stem cell (HSC) function. We measured mRNA expression levels in purified HSCs isolated from a panel of densely genotyped recombinant inbred mouse strains. We mapped quantitative trait loci (QTLs) associated with variation in expression of thousands of transcripts. By comparing the physical transcript position with the location of the controlling QTL, we identified polymorphic cis-acting stem cell genes. We also identified multiple trans-acting control loci that modify expression of large numbers of genes. These groups of coregulated transcripts identify pathways that specify variation in stem cells. We illustrate this concept with the identification of candidate genes involved with HSC turnover. We compared expression QTLs in HSCs and brain from the same mice and identified both shared and tissue-specific QTLs. Our data are accessible through WebQTL, a web-based interface that allows custom genetic linkage analysis and identification of coregulated transcripts.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15711547   Authors: Bystrykh L,Weersing E,Dontje B,Sutton S,Pletcher MT,Wiltshire T,Su AI,Vellenga E,Wang J,Manly KF,Lu L,Chesler EJ,Alberts R,Jansen RC,Williams RW,Cooke MP,de Haan G
Exact source Fig. 4
Related gene sets (show 9 additional gene sets from the source publication)

(show 17 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jean Junior (MSigDB Team)
Source platform or
identifier namespace
AFFY_MG_U74
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 7 genes
Show members (show 8 source identifiers mapped to 7 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.