Mouse Gene Set: CUI_B_CELL_TSLP_RESPONSE_UP


Standard name CUI_B_CELL_TSLP_RESPONSE_UP
Systematic name MM18306
Brief description Genes positively differentially expressed in cell type: B cell upon treatment with cytokine: TSLP in mouse lymph nodes in vivo.
Full description or abstract Cytokines mediate cell-cell communication in the immune system and represent important therapeutic targets. A myriad of studies have highlighted their central role in immune function, yet we lack a global view of the cellular responses of each immune cell type to each cytokine. To address this gap, the authors created the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo. A cytokine-centric view of the dictionary revealed that most cytokines induce highly cell-type-specific responses. For example, the inflammatory cytokine interleukin-1β induces distinct gene programmes in almost every cell type. A cell-type-centric view of the dictionary identified more than 66 cytokine-driven cellular polarization states across immune cell types, including previously uncharacterized states such as an interleukin-18-induced polyfunctional natural killer cell state.
Collection M7: Immunologic Signature
Source publication Pubmed 38057668   Authors: Cui A,Huang T,Li S,Ma A,Pérez JL,Sander C,Keskin DB,Wu CJ,Fraenkel E,Hacohen N
Exact source Supplementary Table 3 Cytokine signatures: DEGs in response to each cytokine treatment in each cell type. 41586_2023_6816_MOESM5_ESM. Genes annotated with Celltype: B cell and Cytokine: TSLP with a Log2FC >0
Related gene sets (show 786 additional gene sets from the source publication)

(show 7 gene sets from any of these authors)
External links www.immune-dictionary.org
Filtered by similarity ?
Source species Mus musculus
Contributed by Anthony Castanza (MSigDB Team)
Source platform or
identifier namespace		 MOUSE_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 9 genes
Show members (show 9 source identifiers mapped to 9 genes)
Version history 2025.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.