Mouse Gene Set: CUI_MACROPHAGE_TNFA_RESPONSE_DN


Standard name CUI_MACROPHAGE_TNFA_RESPONSE_DN
Systematic name MM18750
Brief description Genes negatively differentially expressed in cell type: Macrophage upon treatment with cytokine: TNF-α in mouse lymph nodes in vivo.
Full description or abstract Cytokines mediate cell-cell communication in the immune system and represent important therapeutic targets. A myriad of studies have highlighted their central role in immune function, yet we lack a global view of the cellular responses of each immune cell type to each cytokine. To address this gap, the authors created the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo. A cytokine-centric view of the dictionary revealed that most cytokines induce highly cell-type-specific responses. For example, the inflammatory cytokine interleukin-1β induces distinct gene programmes in almost every cell type. A cell-type-centric view of the dictionary identified more than 66 cytokine-driven cellular polarization states across immune cell types, including previously uncharacterized states such as an interleukin-18-induced polyfunctional natural killer cell state.
Collection M7: Immunologic Signature
Source publication Pubmed 38057668   Authors: Cui A,Huang T,Li S,Ma A,Pérez JL,Sander C,Keskin DB,Wu CJ,Fraenkel E,Hacohen N
Exact source Supplementary Table 3 Cytokine signatures: DEGs in response to each cytokine treatment in each cell type. 41586_2023_6816_MOESM5_ESM. Genes annotated with Celltype: Macrophage and Cytokine: TNF-α with a Log2FC <0
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External links www.immune-dictionary.org
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Source species Mus musculus
Contributed by Anthony Castanza (MSigDB Team)
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identifier namespace		 MOUSE_GENE_SYMBOL
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Version history 2025.1.Mm: First Introduced.

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