Mouse Gene Set: CUI_NK_CELL_IL2_RESPONSE_DN


Standard name CUI_NK_CELL_IL2_RESPONSE_DN
Systematic name MM19022
Brief description Genes negatively differentially expressed in cell type: NK cell upon treatment with cytokine: IL-2 in mouse lymph nodes in vivo.
Full description or abstract Cytokines mediate cell-cell communication in the immune system and represent important therapeutic targets. A myriad of studies have highlighted their central role in immune function, yet we lack a global view of the cellular responses of each immune cell type to each cytokine. To address this gap, the authors created the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo. A cytokine-centric view of the dictionary revealed that most cytokines induce highly cell-type-specific responses. For example, the inflammatory cytokine interleukin-1β induces distinct gene programmes in almost every cell type. A cell-type-centric view of the dictionary identified more than 66 cytokine-driven cellular polarization states across immune cell types, including previously uncharacterized states such as an interleukin-18-induced polyfunctional natural killer cell state.
Collection M7: Immunologic Signature
Source publication Pubmed 38057668   Authors: Cui A,Huang T,Li S,Ma A,Pérez JL,Sander C,Keskin DB,Wu CJ,Fraenkel E,Hacohen N
Exact source Supplementary Table 3 Cytokine signatures: DEGs in response to each cytokine treatment in each cell type. 41586_2023_6816_MOESM5_ESM. Genes annotated with Celltype: NK cell and Cytokine: IL-2 with a Log2FC <0
Related gene sets (show 786 additional gene sets from the source publication)

(show 7 gene sets from any of these authors)
External links www.immune-dictionary.org
Filtered by similarity ?
Source species Mus musculus
Contributed by Anthony Castanza (MSigDB Team)
Source platform or
identifier namespace		 MOUSE_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 355 genes
Show members (show 357 source identifiers mapped to 355 genes)
Version history 2025.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.