Standard name |
GIBBONS_GENETIC_MOUSE_MODEL_LUNG_ADENOCARCINOMA_DOWN_IN_METASTASIS |
Systematic name |
MM2 |
Brief description |
Gene sets differentially expressed in the metastases of non-small cell lung adenocarcinoma tumors from Kras; p53 mice relative to paired primary lung tumors. |
Full description or abstract |
A p53 missense mutation, R175H, found in Li-Fraumeni syndrome patients and in a subset of NSCLC patients, is a structural mutation that exhibits loss of function owing to inactivation of p53 transcriptional activity. Mutation of the corresponding arginine (R172H) in murine p53 has been previously introduced into the mouse as a knock-in allele. To evaluate the importance of p53 as a contributing event in lung tumorigenesis, p53 mice were previously mated with Kras mice, which develop lung adenocarcinomas owing to somatic activation of a latent Kras allele, but rarely metastasize. |
Collection |
M2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 19404390 Authors: Gibbons DL,Lin W,Creighton CJ,Zheng S,Berel D,Yang Y,Raso MG,Liu DD,Wistuba II,Lozano G,Kurie JM |
Exact source |
Table 2 Top named genes differentially expressed (P<0.01) between primary tumors and metastasis. |
Related gene sets |
(show 1 additional gene sets from the source publication)
(show 7 gene sets from the same authors)
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External links |
https://www.ncbi.nlm.nih.gov/pubmed/19404390
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Filtered by similarity ?
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Source species |
Mus musculus |
Contributed by |
Mouse Genome Informatics (MGI) (The Jackson Laboratory (JAX)) |
Source platform or identifier namespace |
AFFY_Mouse430 |
Dataset references |
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Compendia expression profiles ? |
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Advanced query |
Further investigate
these 19 genes
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Show members |
(show 20 source identifiers mapped to 19 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
1416236_a_at |
14012 |
Mpzl2 |
myelin protein zero-like 2 [Source:MG... |
1417275_at |
17153 |
Mal |
myelin and lymphocyte protein, T cell... |
1417797_a_at |
69073 |
Kdf1 |
keratinocyte differentiation factor 1... |
1418639_at |
20389 |
Sftpc |
surfactant associated protein C [Sour... |
1419475_a_at |
13661 |
Ehf |
ets homologous factor [Source:MGI Sym... |
1421404_at |
20309 |
Cxcl15 |
chemokine (C-X-C motif) ligand 15 [So... |
1421802_at |
13586 |
Ear1 |
eosinophil-associated, ribonuclease A... |
1422334_a_at |
20387 |
Sftpa1 |
surfactant associated protein A1 [Sou... |
1422905_s_at |
55990 |
Fmo2 |
flavin containing monooxygenase 2 [So... |
1423323_at |
56753 |
Tacstd2 |
tumor-associated calcium signal trans... |
1423436_at |
14859 |
Gsta3 |
glutathione S-transferase, alpha 3 [S... |
1423914_at |
217310 |
Hid1 |
HID1 domain containing [Source:MGI Sy... |
1426332_a_at |
12739 |
Cldn3 |
claudin 3 [Source:MGI Symbol;Acc:MGI:... |
1429626_at |
20387 |
Sftpa1 |
surfactant associated protein A1 [Sou... |
1435386_at |
22371 |
Vwf |
Von Willebrand factor [Source:MGI Sym... |
1449081_at |
104158 |
Ces1d |
carboxylesterase 1D [Source:MGI Symbo... |
1449184_at |
21946 |
Pglyrp1 |
peptidoglycan recognition protein 1 [... |
1450494_x_at |
26365 |
Ceacam1 |
CEA cell adhesion molecule 1 [Source:... |
1452543_a_at |
22287 |
Scgb1a1 |
secretoglobin, family 1A, member 1 [S... |
1454681_at |
207920 |
Esrp1 |
epithelial splicing regulatory protei... |
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Version history |
2022.1.Mm: First Introduced.
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