Mouse Gene Set: GIBBONS_GENETIC_MOUSE_MODEL_LUNG_ADENOCARCINOMA_DOWN_IN_METASTASIS


Standard name GIBBONS_GENETIC_MOUSE_MODEL_LUNG_ADENOCARCINOMA_DOWN_IN_METASTASIS
Systematic name MM2
Brief description Gene sets differentially expressed in the metastases of non-small cell lung adenocarcinoma tumors from Kras; p53 mice relative to paired primary lung tumors.
Full description or abstract A p53 missense mutation, R175H, found in Li-Fraumeni syndrome patients and in a subset of NSCLC patients, is a structural mutation that exhibits loss of function owing to inactivation of p53 transcriptional activity. Mutation of the corresponding arginine (R172H) in murine p53 has been previously introduced into the mouse as a knock-in allele. To evaluate the importance of p53 as a contributing event in lung tumorigenesis, p53 mice were previously mated with Kras mice, which develop lung adenocarcinomas owing to somatic activation of a latent Kras allele, but rarely metastasize.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 19404390   Authors: Gibbons DL,Lin W,Creighton CJ,Zheng S,Berel D,Yang Y,Raso MG,Liu DD,Wistuba II,Lozano G,Kurie JM
Exact source Table 2 Top named genes differentially expressed (P<0.01) between primary tumors and metastasis.
Related gene sets (show 1 additional gene sets from the source publication)

(show 24 gene sets from any of these authors)
External links https://www.ncbi.nlm.nih.gov/pubmed/19404390
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Source species Mus musculus
Contributed by Mouse Genome Informatics (MGI) (The Jackson Laboratory (JAX))
Source platform or
identifier namespace		 AFFY_Mouse430
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Version history 2022.1.Mm: First Introduced.

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