Standard name |
GIBBONS_GENETIC_MOUSE_MODEL_LUNG_ADENOCARCINOMA_UP_IN_METASTASIS |
Systematic name |
MM1 |
Brief description |
Gene sets differentially expressed in the metastases of non-small cell lung adenocarcinoma tumors from Kras; p53 mice relative to paired primary lung tumors. |
Full description or abstract |
A p53 missense mutation, R175H, found in Li-Fraumeni syndrome patients and in a subset of NSCLC patients, is a structural mutation that exhibits loss of function owing to inactivation of p53 transcriptional activity. Mutation of the corresponding arginine (R172H) in murine p53 has been previously introduced into the mouse as a knock-in allele. To evaluate the importance of p53 as a contributing event in lung tumorigenesis, p53 mice were previously mated with Kras mice, which develop lung adenocarcinomas owing to somatic activation of a latent Kras allele, but rarely metastasize. |
Collection |
M2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 19404390 Authors: Gibbons DL,Lin W,Creighton CJ,Zheng S,Berel D,Yang Y,Raso MG,Liu DD,Wistuba II,Lozano G,Kurie JM |
Exact source |
Table 2 Top named genes differentially expressed (P<0.01) between primary tumors and metastasis. |
Related gene sets |
(show 1 additional gene sets from the source publication)
(show 7 gene sets from the same authors)
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External links |
https://www.ncbi.nlm.nih.gov/pubmed/19404390
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Filtered by similarity ?
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Source species |
Mus musculus |
Contributed by |
Mouse Genome Informatics (MGI) (The Jackson Laboratory (JAX)) |
Source platform or identifier namespace |
AFFY_Mouse430 |
Dataset references |
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Compendia expression profiles ? |
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Advanced query |
Further investigate
these 18 genes
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Show members |
(show 18 source identifiers mapped to 18 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
1416301_a_at |
13591 |
Ebf1 |
early B cell factor 1 [Source:MGI Sym... |
1418588_at |
22360 |
Nrsn1 |
neurensin 1 [Source:MGI Symbol;Acc:MG... |
1419513_a_at |
13605 |
Ect2 |
ect2 oncogene [Source:MGI Symbol;Acc:... |
1419943_s_at |
231869 |
Gm4870 |
predicted gene 4870 [Source:MGI Symbo... |
1420575_at |
17751 |
Mt3 |
metallothionein 3 [Source:MGI Symbol;... |
1422006_at |
19106 |
Eif2ak2 |
eukaryotic translation initiation fac... |
1423439_at |
18534 |
Pck1 |
phosphoenolpyruvate carboxykinase 1, ... |
1423607_at |
17022 |
Lum |
lumican [Source:MGI Symbol;Acc:MGI:10... |
1426920_x_at |
16412 |
Itgb1 |
integrin beta 1 (fibronectin receptor... |
1427465_at |
98660 |
Atp1a2 |
ATPase, Na+/K+ transporting, alpha 2 ... |
1431164_at |
52187 |
Rragd |
Ras-related GTP binding D [Source:MGI... |
1436504_x_at |
11808 |
Apoa4 |
apolipoprotein A-IV [Source:MGI Symbo... |
1438009_at |
319171 |
H2ac24 |
H2A clustered histone 24 [Source:MGI ... |
1448226_at |
20135 |
Rrm2 |
ribonucleotide reductase M2 [Source:M... |
1448314_at |
12534 |
Cdk1 |
cyclin-dependent kinase 1 [Source:MGI... |
1451367_at |
26893 |
Cops6 |
COP9 signalosome subunit 6 [Source:MG... |
1456566_x_at |
56275 |
Rbm14 |
RNA binding motif protein 14 [Source:... |
1460347_at |
16664 |
Krt14 |
keratin 14 [Source:MGI Symbol;Acc:MGI... |
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Version history |
2022.1.Mm: First Introduced.
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