Mouse Gene Set: GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN

For the Human gene set with the same name, see GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN

Standard name GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN
Systematic name MM1070
Brief description Genes down-regulated during differentiation of Oli-Neu cells (oligodendroglial precursor) in response to PD174265 [PubChem=4709].
Full description or abstract Inadequate remyelination of brain white matter lesions has been associated with a failure of oligodendrocyte precursors to differentiate into mature, myelin-producing cells. In order to better understand which genes play a critical role in oligodendrocyte differentiation, we performed time-dependent, genome-wide gene expression studies of mouse Oli-neu cells as they differentiate into process-forming and myelin basic protein-producing cells, following treatment with three different agents. Our data indicate that different inducers activate distinct pathways that ultimately converge into the completely differentiated state, where regulated gene sets overlap maximally. In order to also gain insight into the functional role of genes that are regulated in this process, we silenced 88 of these genes using small interfering RNA and identified multiple repressors of spontaneous differentiation of Oli-neu, most of which were confirmed in rat primary oligodendrocyte precursors cells. Among these repressors were CNP, a well-known myelin constituent, and three phosphatases, each known to negatively control mitogen-activated protein kinase cascades. We show that a novel inhibitor for one of the identified genes, dual-specificity phosphatase DUSP10/MKP5, was also capable of inducing oligodendrocyte differentiation in primary oligodendrocyte precursors. Oligodendrocytic differentiation feedback loops may therefore yield pharmacological targets to treat disease related to dysfunctional myelin deposition.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 19139271   Authors: Gobert RP,Joubert L,Curchod ML,Salvat C,Foucault I,Jorand-Lebrun C,Lamarine M,Peixoto H,Vignaud C,Frémaux C,Jomotte T,Françon B,Alliod C,Bernasconi L,Abderrahim H,Perrin D,Bombrun A,Zanoguera F,Rommel C,Hooft van Huijsduijnen R
Exact source Suppl. file 2: cluster 3
Related gene sets (show 2 additional gene sets from the source publication)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace		 AFFY_Mouse430
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 1122 genes
Show members (show 1695 source identifiers mapped to 1122 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.