Mouse Gene Set: GOBP_REPLICATIVE_SENESCENCE
For the Human gene set with the same name, see GOBP_REPLICATIVE_SENESCENCE
Standard name
GOBP_REPLICATIVE_SENESCENCE
Systematic name
MM10158
Brief description
The process by which normal somatic cells reach an irreversible stage of cell cycle arrest following multiple rounds of replication; this end stage is associated with marked changes in gene expression and function. This is a natural barrier to unlimited proliferation of somatic cells, and is believed to be contolled by telomere shortening. [PMID:17014937, PMID:23061726]
Full description or abstract
Collection
M5: Ontology GO: Gene Ontology GO:BP: GO Biological Process
Source publication
Exact source
GO:0090399
Related gene sets
External links
http://amigo.geneontology.org/amigo/term/GO:0090399
Filtered by similarity ?
Source species
Mus musculus
Contributed by
Gene Ontology (Gene Ontology Consortium)
Source platform or identifier namespace
Mouse_NCBI_Gene_ID
Dataset references
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Advanced query
Further investigate
these 13 genes
Show members
(show 13 source identifiers mapped to 13 genes)
Source Id
NCBI (Entrez) Gene Id
Gene Symbol
Gene Description
11920
11920
Atm
ataxia telangiectasia mutated [Source:MGI ...
12578
12578
Cdkn2a
cyclin dependent kinase inhibitor 2A [Sour...
13870
13870
Ercc1
excision repair cross-complementing rodent...
17380
17380
Mme
membrane metallo endopeptidase [Source:MGI...
18779
18779
Pla2r1
phospholipase A2 receptor 1 [Source:MGI Sy...
18787
18787
Serpine1
serine (or cysteine) peptidase inhibitor, ...
21752
21752
Tert
telomerase reverse transcriptase [Source:M...
22059
22059
Trp53
transformation related protein 53 [Source:...
22427
22427
Wrn
Werner syndrome RecQ like helicase [Source...
245000
245000
Atr
ataxia telangiectasia and Rad3 related [So...
67067
67067
Romo1
reactive oxygen species modulator 1 [Sourc...
68964
68964
Ctc1
CTS telomere maintenance complex component...
93735
93735
Wnt16
wingless-type MMTV integration site family...
Version history
2025.1.Mm: Updated to GO Release 2025-03-16.
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