The process by which normal somatic cells reach an irreversible stage of cell cycle arrest following multiple rounds of replication; this end stage is associated with marked changes in gene expression and function. This is a natural barrier to unlimited proliferation of somatic cells, and is believed to be contolled by telomere shortening. [PMID:17014937, PMID:23061726]
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M5: Ontology GO: Gene Ontology GO:BP: GO Biological Process
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