Mouse Gene Set: GOBP_R_LOOP_PROCESSING
                
               
            
          
  
 
 
 
 
  
    For the Human gene set with the same name, see GOBP_R_LOOP_PROCESSING  
  
  
    Standard name 
    GOBP_R_LOOP_PROCESSING 
   
  
    Systematic name 
    MM16289 
   
  
    Brief description 
    A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability. [PMID:27252122, PMID:28790157, PMID:33986538] 
   
  
    Full description or abstract 
      
   
  
    Collection 
    M5: Ontology       GO: Gene Ontology             GO:BP: GO Biological Process 
   
  
    Source publication 
      
   
  
    Exact source 
    GO:0062176 
   
  
    Related gene sets 
    
      
         
        
      
     
   
  
    External links 
    http://amigo.geneontology.org/amigo/term/GO:0062176  
   
  
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    Source species 
    Mus musculus 
   
  
    Contributed by 
    Gene Ontology (Gene Ontology Consortium) 
   
  
    Source platform or identifier namespace 
    Mouse_NCBI_Gene_ID 
   
  
    Dataset references 
    
       
      
      
      
     
   
  
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        these 9 genes
      
     
   
  
  
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        (show  9 source identifiers mapped to 9 genes)
       
       
      
        
        
          
            Source Id 
            NCBI (Entrez) Gene Id 
            Gene Symbol 
            Gene Description 
           
          
            
              17535 
              17535  
              Mre11a  
              MRE11A homolog A, double strand break repai... 
             
          
            
              19360 
              19360  
              Rad50  
              RAD50 double strand break repair protein [S... 
             
          
            
              20817 
              20817  
              Srpk2  
              serine/arginine-rich protein specific kinas... 
             
          
            
              209011 
              209011  
              Sirt7  
              sirtuin 7 [Source:MGI Symbol;Acc:MGI:2385849] 
             
          
            
              27354 
              27354  
              Nbn  
              nibrin [Source:MGI Symbol;Acc:MGI:1351625] 
             
          
            
              408022 
              408022  
              Primpol  
              primase and polymerase (DNA-directed) [Sour... 
             
          
            
              54446 
              54446  
              Nfat5  
              nuclear factor of activated T cells 5 [Sour... 
             
          
            
              56200 
              56200  
              Ddx21  
              DExD box helicase 21 [Source:MGI Symbol;Acc... 
             
          
            
              74351 
              74351  
              Ddx23  
              DEAD box helicase 23 [Source:MGI Symbol;Acc... 
             
          
        
       
     
   
  
    Version history 
    
      
        
        2025.1.Mm: Updated to GO Release 2025-03-16.
        
      
            
      
     
   
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