Mouse Gene Set: GOCC_METHYLOSOME

For the Human gene set with the same name, see GOCC_METHYLOSOME

Standard name GOCC_METHYLOSOME
Systematic name MM12235
Brief description A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. [PMID:11713266, PMID:11756452]
Full description or abstract  
Collection M5: Ontology
      GO: Gene Ontology
            GO:CC: GO Cellular Component
Source publication  
Exact source GO:0034709
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0034709
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Source species Mus musculus
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Mouse_NCBI_Gene_ID
Dataset references  
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Version history 2026.1.Mm: Updated to GO Release 2025-10-10.


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