Mouse Gene Set: GOMF_UBIQUITIN_ACTIVATING_ENZYME_ACTIVITY
Standard name
GOMF_UBIQUITIN_ACTIVATING_ENZYME_ACTIVITY
Systematic name
MM16461
Brief description
Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. [GOC:BioGRID, Wikipedia:Ubiquitin-activating_enzyme]
Full description or abstract
Collection
M5: Ontology GO: Gene Ontology GO:MF: GO Molecular Function
Source publication
Exact source
GO:0004839
Related gene sets
External links
http://amigo.geneontology.org/amigo/term/GO:0004839
Filtered by similarity ?
Source species
Mus musculus
Contributed by
Gene Ontology (Gene Ontology Consortium)
Source platform or identifier namespace
Mouse_NCBI_Gene_ID
Dataset references
Download gene set
format: grp | gmt | xml | json | TSV metadata
Compute overlaps ?
(show collections to investigate for overlap with this gene set)
Compendia expression profiles ?
NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds )
Mouse Transcriptomic BodyMap compendium
Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query
Further investigate
these 5 genes
Show members
(show 5 source identifiers mapped to 5 genes)
Source Id
NCBI (Entrez) Gene Id
Gene Symbol
Gene Description
22201
22201
Uba1
ubiquitin-like modifier activating enzyme 1 [...
22202
22202
Uba1y
ubiquitin-activating enzyme, Chr Y [Source:MG...
231380
231380
Uba6
ubiquitin-like modifier activating enzyme 6 [...
234664
234664
Nae1
NEDD8 activating enzyme E1 subunit 1 [Source:...
74153
74153
Uba7
ubiquitin-like modifier activating enzyme 7 [...
Version history
2023.1.Mm: First Introduced.
See MSigDB license terms here . Please note that certain gene sets
have special access terms.