Mouse Gene Set: HOWLIN_PUBERTAL_MAMMARY_GLAND

For the Human gene set with the same name, see HOWLIN_PUBERTAL_MAMMARY_GLAND

Standard name HOWLIN_PUBERTAL_MAMMARY_GLAND
Systematic name MM533
Brief description Genes up-regulated in pubertal mammary glands compared to mammary glands from other developmental stages.
Full description or abstract Expression microarray analysis identified CITED1 among a group of genes specifically upregulated in the pubertal mouse mammary gland. At puberty, CITED1 localizes to the luminal epithelial cell population of the mammary ducts and the body cells of the terminal end buds. Generation of CITED1 gene knockout mice showed that homozygous null mutants exhibit retarded mammary ductal growth at puberty and, in addition, dilated ductal structures with a lack of spatial restriction of the subtending branches. Analysis of CITED1 homozygous null and heterozygous null mammary gland gene expression using microarrays suggested that the mammary-specific phenotype seen in the homozygous null females is due to a disturbance in the transcription of a number of key mediators of pubertal ductal morphogenesis. These include estrogen and TGFbeta responsive genes, such as the EGFR/ErbB2 ligand, amphiregulin, whose transcription we suggest is directly or indirectly regulated by CITED1.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 16278680   Authors: Howlin J,McBryan J,Napoletano S,Lambe T,McArdle E,Shioda T,Martin F
Exact source Supplementary Data 1
Related gene sets (show 4 additional gene sets from the source publication)

(show 12 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace		 MOUSE_SEQ_ACCESSION
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 73 genes
Show members (show 86 source identifiers mapped to 73 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.