Mouse Gene Set: IWANAGA_CARCINOGENESIS_BY_KRAS_DN

For the Human gene set with the same name, see IWANAGA_CARCINOGENESIS_BY_KRAS_DN

Standard name IWANAGA_CARCINOGENESIS_BY_KRAS_DN
Systematic name MM753
Brief description Cluster 4: genes down-regulated in lung tissue samples from mice with tumor-bearing genotypes (activated KRAS [GeneID=3845] alone or together with inactivated PTEN [GeneID=5728]).
Full description or abstract Phosphatase and tensin homologue deleted from chromosome 10 (Pten) is expressed aberrantly in non-small cell lung cancer cells, but the role of Pten in lung neoplasia has not been fully elucidated. In this study, we used a genetic approach to inactivate Pten in the bronchial epithelium of mice. Although, by itself, Pten inactivation had no discernible effect on bronchial epithelial histology, it accelerated lung tumorigenesis initiated by oncogenic K-ras, causing more rapid lethality than that induced by oncogenic K-ras alone (8 weeks versus 24 weeks of median duration of survival, respectively). Lung tumors arose in K-ras mutant, Pten-deficient mice that rapidly obstructed bronchial lumina and replaced alveolar spaces. Relative to K-ras mutant tumors, the K-ras mutant, Pten-deficient tumors exhibited more advanced histologic severity and more prominent inflammation and vascularity. Thus, Pten inactivation cooperated with oncogenic K-ras in promoting lung tumorigenesis.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18281487   Authors: Iwanaga K,Yang Y,Raso MG,Ma L,Hanna AE,Thilaganathan N,Moghaddam S,Evans CM,Li H,Cai WW,Sato M,Minna JD,Wu H,Creighton CJ,Demayo FJ,Wistuba II,Kurie JM
Exact source Table 3S: cluster 4
Related gene sets (show 3 additional gene sets from the source publication)

(show 26 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
Source platform or
identifier namespace		 AFFY_Mouse430
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 134 genes
Show members (show 155 source identifiers mapped to 134 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.