Mouse Gene Set: JACKSON_DNMT1_TARGETS_DN

For the Human gene set with the same name, see JACKSON_DNMT1_TARGETS_DN

Standard name JACKSON_DNMT1_TARGETS_DN
Systematic name MM1196
Brief description Genes down-regulated in MEF cells (embryonic fibroblast) upon Cre-lox knockout of DNMT1 [GeneID=1786].
Full description or abstract Cytosine methylation of mammalian DNA is essential for the proper epigenetic regulation of gene expression and maintenance of genomic integrity. To define the mechanism through which demethylated cells die, and to establish a paradigm for identifying genes regulated by DNA methylation, we have generated mice with a conditional allele for the maintenance DNA methyltransferase gene Dnmt1. Cre-mediated deletion of Dnmt1 causes demethylation of cultured fibroblasts and a uniform p53-dependent cell death. Mutational inactivation of Trp53 partially rescues the demethylated fibroblasts for up to five population doublings in culture. Oligonucleotide microarray analysis showed that up to 10% of genes are aberrantly expressed in demethylated fibroblasts. Our results demonstrate that loss of Dnmt1 causes cell-type-specific changes in gene expression that impinge on several pathways, including expression of imprinted genes, cell-cycle control, growth factor/receptor signal transduction and mobilization of retroelements.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 11137995   Authors: Jackson-Grusby L,Beard C,Possemato R,Tudor M,Fambrough D,Csankovszki G,Dausman J,Lee P,Wilson C,Lander E,Jaenisch R
Exact source Table 2: Fold <= -2
Related gene sets (show 1 additional gene sets from the source publication)

(show 51 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by John Newman (University of Washington)
Source platform or
identifier namespace		 AFFY_Mu11K
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 23 genes
Show members (show 27 source identifiers mapped to 23 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.