Mouse Gene Set: MARSON_FOXP3_TARGETS_UP

For the Human gene set with the same name, see MARSON_FOXP3_TARGETS_UP

Standard name MARSON_FOXP3_TARGETS_UP
Systematic name MM846
Brief description Genes up-regulated by FOXP3 [GeneID=50943] in both ex vivo and hybridoma cells.
Full description or abstract Foxp3+CD4+CD25+ regulatory T (T(reg)) cells are essential for the prevention of autoimmunity. T(reg) cells have an attenuated cytokine response to T-cell receptor stimulation, and can suppress the proliferation and effector function of neighbouring T cells. The forkhead transcription factor Foxp3 (forkhead box P3) is selectively expressed in T(reg) cells, is required for T(reg) development and function, and is sufficient to induce a T(reg) phenotype in conventional CD4+CD25- T cells. Mutations in Foxp3 cause severe, multi-organ autoimmunity in both human and mouse. FOXP3 can cooperate in a DNA-binding complex with NFAT (nuclear factor of activated T cells) to regulate the transcription of several known target genes. However, the global set of genes regulated directly by Foxp3 is not known and consequently, how this transcription factor controls the gene expression programme for T(reg) function is not understood. Here we identify Foxp3 target genes and report that many of these are key modulators of T-cell activation and function. Remarkably, the predominant, although not exclusive, effect of Foxp3 occupancy is to suppress the activation of target genes on T-cell stimulation. Foxp3 suppression of its targets appears to be crucial for the normal function of T(reg) cells, because overactive variants of some target genes are known to be associated with autoimmune disease.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17237765   Authors: Marson A,Kretschmer K,Frampton GM,Jacobsen ES,Polansky JK,MacIsaac KD,Levine SS,Fraenkel E,von Boehmer H,Young RA
Exact source Table 10S: Ex vivo > 0 & hybridoma > 0
Related gene sets (show 6 additional gene sets from the source publication)

(show 787 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace		 AFFY_Mouse430
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 67 genes
Show members (show 69 source identifiers mapped to 67 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.