Mouse Gene Set: MATSUDA_NATURAL_KILLER_DIFFERENTIATION

For the Human gene set with the same name, see MATSUDA_NATURAL_KILLER_DIFFERENTIATION

Standard name MATSUDA_NATURAL_KILLER_DIFFERENTIATION
Systematic name MM1008
Brief description Genes changed between developmental stages of Valpha14i natural killer T lymphocyte cells (NKT).
Full description or abstract Valpha14i natural killer T (NKT)-cell function has been implicated in a number of disease conditions. The molecular events that drive Valpha14i NKT-cell development remain elusive. We recently showed that T-bet is required for the terminal maturation of these cells. Here we identify some of the genetic targets of T-bet during Valpha14i NKT-cell lineage development. Microarray gene-expression analyses on developing Valpha14i NKT cells were performed and provide a molecular framework to study these maturation events. In vitro ectopic expression of T-bet in immature Valpha14i NKT cells, which do not yet express T-bet, was sufficient to promote Valpha14i NKT-cell maturation, driving the expression of multiple genes, including those that participate in migration, survival, and effector functions. By regulating the expression of T-helper 1 (Th1)-associated cytokines, chemokines, chemokine receptors, and molecules involved in cytolysis, T-bet defines the unique lineage attributes of mature Valpha14i NKT cells and acts to link these attributes to a developmental process.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 16357323   Authors: Matsuda JL,Zhang Q,Ndonye R,Richardson SK,Howell AR,Gapin L
Exact source Table 1S
Related gene sets  
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Kevin Vogelsang (MSigDB Team)
Source platform or
identifier namespace		 AFFY_Mouse430
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 510 genes
Show members (show 598 source identifiers mapped to 510 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.