Mouse Gene Set: MORI_LARGE_PRE_BII_LYMPHOCYTE_UP

For the Human gene set with the same name, see MORI_LARGE_PRE_BII_LYMPHOCYTE_UP

Standard name MORI_LARGE_PRE_BII_LYMPHOCYTE_UP
Systematic name MM1137
Brief description Up-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: the Large Pre-BII stage.
Full description or abstract The Emu-myc transgenic mouse has provided a valuable model for the study of B-cell lymphoma. Making use of gene expression analysis and, in particular, expression signatures of cell signaling pathway activation, we now show that several forms of B lymphoma can be identified in the Emu-myc mice associated with time of tumor onset. Furthermore, one form of Emu-myc tumor with pre-B character is shown to resemble human Burkitt lymphoma, whereas others exhibit more differentiated B-cell characteristics and show similarity with human diffuse large B-cell lymphoma in the pattern of gene expression, as well as oncogenic pathway activation. Importantly, we show that signatures of oncogenic pathway activity provide further dissection of the spectrum of diffuse large B-cell lymphoma, identifying a subset of patients who have very poor prognosis and could benefit from more aggressive or novel therapeutic strategies. Taken together, these studies provide insight into the complexity of the oncogenic process and a novel strategy for dissecting the heterogeneity of B lymphoma.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18922927   Authors: Mori S,Rempel RE,Chang JT,Yao G,Lagoo AS,Potti A,Bild A,Nevins JR
Exact source Table 4S: Large Pre-BII
Related gene sets (show 13 additional gene sets from the source publication)

(show 3 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
Source platform or
identifier namespace		 AFFY_Mu11K
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 88 genes
Show members (show 113 source identifiers mapped to 88 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.