Mouse Gene Set: UEDA_CENTRAL_CLOCK

For the Human gene set with the same name, see UEDA_CENTRAL_CLOCK

Standard name UEDA_CENTRAL_CLOCK
Systematic name MM1141
Brief description Molecular timetable composed of 96 time-indicating genes (103 probes) in the central (suprachiasmatic nucleus (SCN)) clock.
Full description or abstract Detection of individual body time (BT) via a single-time-point assay has been a longstanding unfulfilled dream in medicine, because BT information can be exploited to maximize potency and minimize toxicity during drug administration and thus will enable highly optimized medication. To achieve this dream, we created a molecular timetable composed of >100 time-indicating genes, whose gene expression levels can represent internal BT. Here we describe a robust method called the molecular-timetable method for BT detection from a single-time-point expression profile. The power of this method is demonstrated by the sensitive and accurate detection of BT and the sensitive diagnosis of rhythm disorders. These results demonstrate the feasibility of BT detection based on single-time-point sampling, suggest the potential for expression-based diagnosis of rhythm disorders, and may translate functional genomics into chronotherapy and personalized medicine.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15273285   Authors: Ueda HR,Chen W,Minami Y,Honma S,Honma K,Iino M,Hashimoto S
Exact source Table 2S
Related gene sets (show 1 additional gene sets from the source publication)

(show 1 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Kate Stafford (MSigDB Team)
Source platform or
identifier namespace		 AFFY_MG_U74
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 91 genes
Show members (show 103 source identifiers mapped to 91 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.