Mouse Gene Set: YE_BELLE_SENCAF_CONSENSUS


Standard name YE_BELLE_SENCAF_CONSENSUS
Systematic name MM19753
Brief description Genes upregulated in senescent cancer assoicated fibroblasts.
Full description or abstract This gene set represents a consensus senescent cancer-associated fibroblast (senCAF) signature derived from two independent studies of stromal senescence in breast cancer (Ye et al., Cancer Discovery, 2024; Belle et al., Cancer Discovery, 2024) and bresat bone metastasis (Faget et al., Cancer Discovery 2023) . Genes were extracted from CAF-adapted senescence modules in each study and merged with deduplication. The signature captures core senescence markers (CDKN1A, CDKN2A), SASP cytokines (IL6, IL8, CCL2, CXCL1/2/3), stress-response effectors (ATF3, HSPB1, DUSP1, ZFP36 family), ECM/fibrotic remodeling genes (COL1A1/1A2, COL12A1, FN1, THBS1/2), and senescence-associated osteogenic and immunomodulatory factors (SPP1, TGFB3, CD276, TNFSF11). This integrated signature reflects shared, reproducible features of stromal senescence across datasets and can be used for GSEA, ssGSEA, and stromal senescence scoring in bulk or single-cell transcriptomic data.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication  
Exact source The set was derived from the consensus genes of the following publications: PMID: 38683161 and 38683144 and 36883955
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Source species Mus musculus
Contributed by Sheila Stewart (Washington University)
Source platform or
identifier namespace		 MOUSE_GENE_SYMBOL
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Version history 2026.1.Mm: First Introduced.


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