Mouse Gene Set: ZENG_GU_ICB_CONTROL_METAGENE_25_PRECICTIVE_ICB_RESPONSE


Standard name ZENG_GU_ICB_CONTROL_METAGENE_25_PRECICTIVE_ICB_RESPONSE
Systematic name MM17079
Brief description Metagene_25 is enriched in SKCM, which has a high response rate to anti-PD1 (Fig. 4D). The top-ranked genes in metagene_25 were Pdcd1, Cd8b1, and Cd3g (Fig. 5A), representative of CTL infiltration. Gene set enrichment analysis of genes in metagene_25 identified pathways of immunoregulatory interactions and antigen processing and presentation (Fig. 5, B and C). Metagene_25 also shows a positive correlation with improved patient survival and increased CD8+ T cell infiltration (Fig. 5, D and E).
Full description or abstract Most patients with cancer are refractory to immune checkpoint blockade (ICB) therapy, and proper patient stratification remains an open question. Primary patient data suffer from high heterogeneity, low accessibility, and lack of proper controls. In contrast, syngeneic mouse tumor models enable controlled experiments with ICB treatments. Using transcriptomic and experimental variables from >700 ICB-treated/control syngeneic mouse tumors, [this study] developed a machine learning framework to model tumor immunity and identify factors influencing ICB response. Projected on human immunotherapy trial data, [this study] found that the model can predict clinical ICB response. [This study] further applied the model to predicting ICB-responsive/resistant cancer types in The Cancer Genome Atlas, which agreed well with existing clinical reports.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 36240281   Authors: Zeng Z,Gu SS,Wong CJ,Yang L,Ouardaoui N,Li D,Zhang W,Brown M,Liu XS
Exact source Table S5. Top genes in different metagenes (control samples): metageneor25
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Source species Mus musculus
Contributed by Anthony Castanza (MSigDB Team)
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identifier namespace		 MOUSE_GENE_SYMBOL
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