Mouse Gene Set: ZENG_GU_ICB_CONTROL_METAGENE_3_PRECICTIVE_ICB_RESPONSE


Standard name ZENG_GU_ICB_CONTROL_METAGENE_3_PRECICTIVE_ICB_RESPONSE
Systematic name MM17081
Brief description The top-ranked gene in metagene_3 was Lats2, a tumor suppressor gene, which has been shown to suppress Yes associated protein (YAP) activity and cell proliferation
Full description or abstract Most patients with cancer are refractory to immune checkpoint blockade (ICB) therapy, and proper patient stratification remains an open question. Primary patient data suffer from high heterogeneity, low accessibility, and lack of proper controls. In contrast, syngeneic mouse tumor models enable controlled experiments with ICB treatments. Using transcriptomic and experimental variables from >700 ICB-treated/control syngeneic mouse tumors, [this study] developed a machine learning framework to model tumor immunity and identify factors influencing ICB response. Projected on human immunotherapy trial data, [this study] found that the model can predict clinical ICB response. [This study] further applied the model to predicting ICB-responsive/resistant cancer types in The Cancer Genome Atlas, which agreed well with existing clinical reports.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 36240281   Authors: Zeng Z,Gu SS,Wong CJ,Yang L,Ouardaoui N,Li D,Zhang W,Brown M,Liu XS
Exact source Table S5. Top genes in different metagenes (control samples): metageneor3
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Source species Mus musculus
Contributed by Anthony Castanza (MSigDB Team)
Source platform or
identifier namespace		 MOUSE_GENE_SYMBOL
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Version history 2023.2.Mm: First Introduced.

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