Mouse Gene Set: ZHANG_GATA6_TARGETS_DN

For the Human gene set with the same name, see ZHANG_GATA6_TARGETS_DN

Standard name ZHANG_GATA6_TARGETS_DN
Systematic name MM1226
Brief description Genes down-regulated after cre-lox knockout of GATA6 [GeneID=2627] in airway epithelium.
Full description or abstract Epithelial organs, including the lung, are known to possess regenerative abilities through activation of endogenous stem cell populations, but the molecular pathways regulating stem cell expansion and regeneration are not well understood. Here we show that Gata6 regulates the temporal appearance and number of bronchioalveolar stem cells (BASCs) in the lung, its absence in Gata6-null lung epithelium leading to the precocious appearance of BASCs and concurrent loss in epithelial differentiation. This expansion of BASCs was the result of a pronounced increase in canonical Wnt signaling in lung epithelium upon loss of Gata6. Expression of the noncanonical Wnt receptor Fzd2 was downregulated in Gata6 mutants and increased Fzd2 or decreased beta-catenin expression rescued, in part, the lung epithelial defects in Gata6 mutants. During lung epithelial regeneration, canonical Wnt signaling was activated in the niche containing BASCs and forced activation of Wnt signaling led to a large increase in BASC numbers. Moreover, Gata6 was required for proper lung epithelial regeneration, and postnatal loss of Gata6 led to increased BASC expansion and decreased differentiation. Together, these data demonstrate that Gata6-regulated Wnt signaling controls the balance between progenitor expansion and epithelial differentiation required for both lung development and regeneration.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18536717   Authors: Zhang Y,Goss AM,Cohen ED,Kadzik R,Lepore JJ,Muthukumaraswamy K,Yang J,DeMayo FJ,Whitsett JA,Parmacek MS,Morrisey EE
Exact source Fig 4a
Related gene sets (show 1 additional gene sets from the source publication)

(show 5 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
Source platform or
identifier namespace		 MOUSE_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 64 genes
Show members (show 68 source identifiers mapped to 64 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.