Mouse Gene Set: ZHENG_IL22_SIGNALING_DN

For the Human gene set with the same name, see ZHENG_IL22_SIGNALING_DN

Standard name ZHENG_IL22_SIGNALING_DN
Systematic name MM763
Brief description Genes down-regulated in ex-vivo colonic tissue after treatment with IL22 [GeneID=50616].
Full description or abstract Infections by attaching and effacing (A/E) bacterial pathogens, such as Escherichia coli O157:H7, pose a serious threat to public health. Using a mouse A/E pathogen, Citrobacter rodentium, we show that interleukin-22 (IL-22) has a crucial role in the early phase of host defense against C. rodentium. Infection of IL-22 knockout mice results in increased intestinal epithelial damage, systemic bacterial burden and mortality. We also find that IL-23 is required for the early induction of IL-22 during C. rodentium infection, and adaptive immunity is not essential for the protective role of IL-22 in this model. Instead, IL-22 is required for the direct induction of the Reg family of antimicrobial proteins, including RegIIIbeta and RegIIIgamma, in colonic epithelial cells. Exogenous mouse or human RegIIIgamma substantially improves survival of IL-22 knockout mice after C. rodentium infection. Together, our data identify a new innate immune function for IL-22 in regulating early defense mechanisms against A/E bacterial pathogens.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18264109   Authors: Zheng Y,Valdez PA,Danilenko DM,Hu Y,Sa SM,Gong Q,Abbas AR,Modrusan Z,Ghilardi N,de Sauvage FJ,Ouyang W
Exact source Table 1S
Related gene sets (show 1 additional gene sets from the source publication)

(show 18 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
Source platform or
identifier namespace		 MOUSE_SEQ_ACCESSION
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 51 genes
Show members (show 75 source identifiers mapped to 51 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.