Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Diabetes_collapsed.gct |
| Phenotype | DMT |
| GeneSet | C2.symbols.gmt#ST_T_Cell_Signal_Transduction |
| Enrichment Score (ES) | -0.42926073 |
| Normalized Enrichment Score (NES) | -1.5892211 |
| Nominal p-value | 0.025641026 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.83 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RES | CORE_ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | NFKBIL1 | NFKBIL1 StanfordSource, GeneCards | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | 525 | 0.321 | 0.0176 | No |
| 2 | PAK7 | PAK7 StanfordSource, GeneCards | p21(CDKN1A)-activated kinase 7 | 1287 | 0.249 | 0.0077 | No |
| 3 | ITPKA | ITPKA StanfordSource, GeneCards | inositol 1,4,5-trisphosphate 3-kinase A | 1674 | 0.222 | 0.0183 | No |
| 4 | RASGRP3 | RASGRP3 StanfordSource, GeneCards | RAS guanyl releasing protein 3 (calcium and DAG-regulated) | 1962 | 0.206 | 0.0328 | No |
| 5 | PAK6 | PAK6 StanfordSource, GeneCards | p21(CDKN1A)-activated kinase 6 | 3786 | 0.125 | -0.0681 | No |
| 6 | LCK | LCK StanfordSource, GeneCards | lymphocyte-specific protein tyrosine kinase | 4161 | 0.112 | -0.0747 | No |
| 7 | NFKB1 | NFKB1 StanfordSource, GeneCards | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 4741 | 0.094 | -0.0979 | No |
| 8 | CSK | CSK StanfordSource, GeneCards | c-src tyrosine kinase | 5869 | 0.060 | -0.1630 | No |
| 9 | FBXW7 | FBXW7 StanfordSource, GeneCards | F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) | 6783 | 0.034 | -0.2183 | No |
| 10 | ITK | ITK StanfordSource, GeneCards | IL2-inducible T-cell kinase | 7186 | 0.022 | -0.2414 | No |
| 11 | NFKBIA | NFKBIA StanfordSource, GeneCards | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 8112 | -0.004 | -0.3025 | No |
| 12 | NFKBIE | NFKBIE StanfordSource, GeneCards | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 8530 | -0.016 | -0.3277 | No |
| 13 | CD3D | CD3D StanfordSource, GeneCards | CD3D antigen, delta polypeptide (TiT3 complex) | 8585 | -0.017 | -0.3284 | No |
| 14 | SOS1 | SOS1 StanfordSource, GeneCards | son of sevenless homolog 1 (Drosophila) | 8678 | -0.020 | -0.3314 | No |
| 15 | NFAT5 | NFAT5 StanfordSource, GeneCards | nuclear factor of activated T-cells 5, tonicity-responsive | 8738 | -0.021 | -0.3318 | No |
| 16 | PLCG1 | PLCG1 StanfordSource, GeneCards | phospholipase C, gamma 1 (formerly subtype 148) | 8810 | -0.023 | -0.3327 | No |
| 17 | NCK1 | NCK1 StanfordSource, GeneCards | NCK adaptor protein 1 | 10261 | -0.070 | -0.4179 | Yes |
| 18 | PAK3 | PAK3 StanfordSource, GeneCards | p21 (CDKN1A)-activated kinase 3 | 10373 | -0.073 | -0.4132 | Yes |
| 19 | RAF1 | RAF1 StanfordSource, GeneCards | v-raf-1 murine leukemia viral oncogene homolog 1 | 10478 | -0.078 | -0.4075 | Yes |
| 20 | GRB2 | GRB2 StanfordSource, GeneCards | growth factor receptor-bound protein 2 | 10756 | -0.087 | -0.4117 | Yes |
| 21 | DTYMK | DTYMK StanfordSource, GeneCards | deoxythymidylate kinase (thymidylate kinase) | 10773 | -0.088 | -0.3984 | Yes |
| 22 | CBL | CBL StanfordSource, GeneCards | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 11007 | -0.096 | -0.3983 | Yes |
| 23 | PAK4 | PAK4 StanfordSource, GeneCards | p21(CDKN1A)-activated kinase 4 | 11091 | -0.099 | -0.3877 | Yes |
| 24 | VAV1 | VAV1 StanfordSource, GeneCards | vav 1 oncogene | 11162 | -0.101 | -0.3758 | Yes |
| 25 | ZAP70 | ZAP70 StanfordSource, GeneCards | zeta-chain (TCR) associated protein kinase 70kDa | 11163 | -0.101 | -0.3593 | Yes |
| 26 | CD28 | CD28 StanfordSource, GeneCards | CD28 antigen (Tp44) | 11318 | -0.106 | -0.3522 | Yes |
| 27 | ITPKB | ITPKB StanfordSource, GeneCards | inositol 1,4,5-trisphosphate 3-kinase B | 11386 | -0.109 | -0.3388 | Yes |
| 28 | LAT | LAT StanfordSource, GeneCards | linker for activation of T cells | 11644 | -0.119 | -0.3365 | Yes |
| 29 | NFKB2 | NFKB2 StanfordSource, GeneCards | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 11730 | -0.122 | -0.3223 | Yes |
| 30 | GRAP2 | GRAP2 StanfordSource, GeneCards | GRB2-related adaptor protein 2 | 12362 | -0.150 | -0.3398 | Yes |
| 31 | RASGRP1 | RASGRP1 StanfordSource, GeneCards | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | 12375 | -0.150 | -0.3160 | Yes |
| 32 | PTPRC | PTPRC StanfordSource, GeneCards | protein tyrosine phosphatase, receptor type, C | 12440 | -0.153 | -0.2953 | Yes |
| 33 | MAPK1 | MAPK1 StanfordSource, GeneCards | mitogen-activated protein kinase 1 | 13258 | -0.200 | -0.3169 | Yes |
| 34 | SOS2 | SOS2 StanfordSource, GeneCards | son of sevenless homolog 2 (Drosophila) | 13426 | -0.211 | -0.2935 | Yes |
| 35 | EPHB2 | EPHB2 StanfordSource, GeneCards | EphB2 | 13443 | -0.212 | -0.2599 | Yes |
| 36 | RASGRP2 | RASGRP2 StanfordSource, GeneCards | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | 13869 | -0.244 | -0.2482 | Yes |
| 37 | PAK1 | PAK1 StanfordSource, GeneCards | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 14220 | -0.281 | -0.2255 | Yes |
| 38 | CTLA4 | CTLA4 StanfordSource, GeneCards | cytotoxic T-lymphocyte-associated protein 4 | 14235 | -0.283 | -0.1801 | Yes |
| 39 | LCP2 | LCP2 StanfordSource, GeneCards | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 14294 | -0.290 | -0.1365 | Yes |
| 40 | NFKBIB | NFKBIB StanfordSource, GeneCards | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 14439 | -0.309 | -0.0955 | Yes |
| 41 | DAG1 | DAG1 StanfordSource, GeneCards | dystroglycan 1 (dystrophin-associated glycoprotein 1) | 14785 | -0.374 | -0.0572 | Yes |
| 42 | PAK2 | PAK2 StanfordSource, GeneCards | p21 (CDKN1A)-activated kinase 2 | 14982 | -0.459 | 0.0049 | Yes |
