Details for gene set chr21q22[GSEA]

Table: GSEA Results Summary

Dataset	Gender_collapsed.gct
Phenotype	MALE
GeneSet	C1.symbols.gmt#chr21q22
Enrichment Score (ES)	0.312102
Normalized Enrichment Score (NES)	1.1927809
Nominal p-value	0.20787401
FDR q-value	1.0
FWER p-Value	0.949

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RES	CORE_ENRICHMENT
1	TMPRSS3	TMPRSS3 StanfordSource, GeneCards	transmembrane protease, serine 3	150	0.430	0.0197	Yes
2	TIAM1	TIAM1 StanfordSource, GeneCards	T-cell lymphoma invasion and metastasis 1	200	0.409	0.0447	Yes
3	C21orf62	C21orf62 StanfordSource, GeneCards	chromosome 21 open reading frame 62	393	0.357	0.0565	Yes
4	COL6A1	COL6A1 StanfordSource, GeneCards	collagen, type VI, alpha 1	420	0.352	0.0790	Yes
5	C21orf55	C21orf55 StanfordSource, GeneCards	chromosome 21 open reading frame 55	567	0.326	0.0917	Yes
6	C21orf25	C21orf25 StanfordSource, GeneCards	chromosome 21 open reading frame 25	599	0.319	0.1117	Yes
7	S100B	S100B StanfordSource, GeneCards	S100 calcium binding protein, beta (neural)	745	0.301	0.1228	Yes
8	RIPK4	RIPK4 StanfordSource, GeneCards	receptor-interacting serine-threonine kinase 4	901	0.284	0.1320	Yes
9	AIRE	AIRE StanfordSource, GeneCards	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	1030	0.271	0.1422	Yes
10	HLCS	HLCS StanfordSource, GeneCards	holocarboxylase synthetase (biotin-[proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)	1056	0.269	0.1591	Yes
11	RUNX1	RUNX1 StanfordSource, GeneCards	runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)	1163	0.258	0.1699	Yes
12	CRYZL1	CRYZL1 StanfordSource, GeneCards	crystallin, zeta (quinone reductase)-like 1	1592	0.227	0.1569	Yes
13	C21orf18	C21orf18 StanfordSource, GeneCards	chromosome 21 open reading frame 18	1740	0.219	0.1622	Yes
14	C21orf2	C21orf2 StanfordSource, GeneCards	chromosome 21 open reading frame 2	1778	0.217	0.1747	Yes
15	KCNJ15	KCNJ15 StanfordSource, GeneCards	potassium inwardly-rectifying channel, subfamily J, member 15	1826	0.214	0.1863	Yes
16	CLDN8	CLDN8 StanfordSource, GeneCards	claudin 8	1833	0.213	0.2007	Yes
17	ADARB1	ADARB1 StanfordSource, GeneCards	adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)	1857	0.212	0.2138	Yes
18	C21orf5	C21orf5 StanfordSource, GeneCards	chromosome 21 open reading frame 5	1874	0.211	0.2273	Yes
19	DSCR5	DSCR5 StanfordSource, GeneCards	Down syndrome critical region gene 5	1949	0.207	0.2366	Yes
20	WRB	WRB StanfordSource, GeneCards	tryptophan rich basic protein	2084	0.199	0.2414	Yes
21	TFF1	TFF1 StanfordSource, GeneCards	trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in)	2494	0.180	0.2264	Yes
22	C21orf45	C21orf45 StanfordSource, GeneCards	chromosome 21 open reading frame 45	2628	0.175	0.2296	Yes
23	KCNJ6	KCNJ6 StanfordSource, GeneCards	potassium inwardly-rectifying channel, subfamily J, member 6	2657	0.173	0.2397	Yes
24	CLDN14	CLDN14 StanfordSource, GeneCards	claudin 14	2697	0.171	0.2489	Yes
25	DONSON	DONSON StanfordSource, GeneCards	downstream neighbor of SON	2777	0.168	0.2552	Yes
26	CHAF1B	CHAF1B StanfordSource, GeneCards	chromatin assembly factor 1, subunit B (p60)	2981	0.159	0.2526	Yes
27	MRPS6	MRPS6 StanfordSource, GeneCards	mitochondrial ribosomal protein S6	3092	0.154	0.2560	Yes
28	TRPM2	TRPM2 StanfordSource, GeneCards	transient receptor potential cation channel, subfamily M, member 2	3184	0.150	0.2602	Yes
29	SFRS15	SFRS15 StanfordSource, GeneCards	splicing factor, arginine/serine-rich 15	3287	0.146	0.2635	Yes
30	WDR4	WDR4 StanfordSource, GeneCards	WD repeat domain 4	3298	0.145	0.2729	Yes
31	C21orf33	C21orf33 StanfordSource, GeneCards	chromosome 21 open reading frame 33	3325	0.145	0.2811	Yes
32	SUMO3	SUMO3 StanfordSource, GeneCards	SMT3 suppressor of mif two 3 homolog 3 (yeast)	3348	0.144	0.2896	Yes
33	B3GALT5	B3GALT5 StanfordSource, GeneCards	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5	3372	0.143	0.2979	Yes
34	IFNAR2	IFNAR2 StanfordSource, GeneCards	interferon (alpha, beta and omega) receptor 2	3398	0.141	0.3060	Yes
35	TTC3	TTC3 StanfordSource, GeneCards	tetratricopeptide repeat domain 3	3582	0.134	0.3030	Yes
36	COL18A1	COL18A1 StanfordSource, GeneCards	collagen, type XVIII, alpha 1	3814	0.125	0.2962	Yes
37	C21orf108	C21orf108 StanfordSource, GeneCards	chromosome 21 open reading frame 108	3835	0.124	0.3035	Yes
38	COL6A2	COL6A2 StanfordSource, GeneCards	collagen, type VI, alpha 2	3879	0.123	0.3091	Yes
39	SH3BGR	SH3BGR StanfordSource, GeneCards	SH3 domain binding glutamic acid-rich protein	3958	0.119	0.3121	Yes
40	DSCAM	DSCAM StanfordSource, GeneCards	Down syndrome cell adhesion molecule	4224	0.110	0.3020	No
41	CSTB	CSTB StanfordSource, GeneCards	cystatin B (stefin B)	4279	0.108	0.3059	No
42	SYNJ1	SYNJ1 StanfordSource, GeneCards	synaptojanin 1	4538	0.100	0.2955	No
43	CRYAA	CRYAA StanfordSource, GeneCards	crystallin, alpha A	4619	0.098	0.2969	No
44	MX2	MX2 StanfordSource, GeneCards	myxovirus (influenza virus) resistance 2 (mouse)	4807	0.092	0.2907	No
45	MCM3APAS	MCM3APAS StanfordSource, GeneCards	MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein, antisense	4931	0.088	0.2886	No
46	KCNE1	KCNE1 StanfordSource, GeneCards	potassium voltage-gated channel, Isk-related family, member 1	4963	0.087	0.2925	No
47	POFUT2	POFUT2 StanfordSource, GeneCards	protein O-fucosyltransferase 2	5169	0.080	0.2844	No
48	LSS	LSS StanfordSource, GeneCards	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	5179	0.080	0.2893	No
49	ZCWCC3	ZCWCC3 StanfordSource, GeneCards	zinc finger, CW-type with coiled-coil domain 3	5276	0.077	0.2882	No
50	KCNE2	KCNE2 StanfordSource, GeneCards	potassium voltage-gated channel, Isk-related family, member 2	5473	0.070	0.2799	No
51	ETS2	ETS2 StanfordSource, GeneCards	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	5524	0.068	0.2813	No
52	DSCR6	DSCR6 StanfordSource, GeneCards	Down syndrome critical region gene 6	5904	0.058	0.2599	No
53	DYRK1A	DYRK1A StanfordSource, GeneCards	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	6054	0.054	0.2537	No
54	HRMT1L1	HRMT1L1 StanfordSource, GeneCards	HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae)	6065	0.053	0.2567	No
55	IFNGR2	IFNGR2 StanfordSource, GeneCards	interferon gamma receptor 2 (interferon gamma transducer 1)	6347	0.045	0.2410	No
56	AGPAT3	AGPAT3 StanfordSource, GeneCards	1-acylglycerol-3-phosphate O-acyltransferase 3	6478	0.041	0.2352	No
57	TMPRSS2	TMPRSS2 StanfordSource, GeneCards	transmembrane protease, serine 2	6612	0.037	0.2289	No
58	C21orf59	C21orf59 StanfordSource, GeneCards	chromosome 21 open reading frame 59	6871	0.030	0.2136	No
59	HUNK	HUNK StanfordSource, GeneCards	hormonally upregulated Neu-associated kinase	6889	0.029	0.2145	No
60	PCP4	PCP4 StanfordSource, GeneCards	Purkinje cell protein 4	7185	0.021	0.1963	No
61	CBR1	CBR1 StanfordSource, GeneCards	carbonyl reductase 1	7263	0.018	0.1924	No
62	HSF2BP	HSF2BP StanfordSource, GeneCards	heat shock transcription factor 2 binding protein	7293	0.017	0.1916	No
63	PCNT2	PCNT2 StanfordSource, GeneCards	pericentrin 2 (kendrin)	7340	0.016	0.1896	No
64	CBS	CBS StanfordSource, GeneCards	cystathionine-beta-synthase	7532	0.010	0.1775	No
65	PFKL	PFKL StanfordSource, GeneCards	phosphofructokinase, liver	7613	0.008	0.1727	No
66	TFF2	TFF2 StanfordSource, GeneCards	trefoil factor 2 (spasmolytic protein 1)	7635	0.007	0.1718	No
67	SOD1	SOD1 StanfordSource, GeneCards	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	7677	0.006	0.1694	No
68	ABCG1	ABCG1 StanfordSource, GeneCards	ATP-binding cassette, sub-family G (WHITE), member 1	7818	0.001	0.1601	No
69	PWP2H	PWP2H StanfordSource, GeneCards	PWP2 periodic tryptophan protein homolog (yeast)	8027	-0.005	0.1465	No
70	OLIG2	OLIG2 StanfordSource, GeneCards	oligodendrocyte lineage transcription factor 2	8029	-0.005	0.1468	No
71	DSCR3	DSCR3 StanfordSource, GeneCards	Down syndrome critical region gene 3	8045	-0.005	0.1461	No
72	SNF1LK	SNF1LK StanfordSource, GeneCards	SNF1-like kinase	8266	-0.011	0.1322	No
73	SLC19A1	SLC19A1 StanfordSource, GeneCards	solute carrier family 19 (folate transporter), member 1	8402	-0.015	0.1242	No
74	MCM3AP	MCM3AP StanfordSource, GeneCards	MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein	8406	-0.015	0.1250	No
75	ITGB2	ITGB2 StanfordSource, GeneCards	integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)	8505	-0.018	0.1197	No
76	C21orf106	C21orf106 StanfordSource, GeneCards	chromosome 21 open reading frame 106	8749	-0.024	0.1051	No
77	DSCR1	DSCR1 StanfordSource, GeneCards	Down syndrome critical region gene 1	8957	-0.030	0.0933	No
78	C21orf66	C21orf66 StanfordSource, GeneCards	chromosome 21 open reading frame 66	9011	-0.031	0.0919	No
79	PDE9A	PDE9A StanfordSource, GeneCards	phosphodiesterase 9A	9256	-0.038	0.0782	No
80	IFNAR1	IFNAR1 StanfordSource, GeneCards	interferon (alpha, beta and omega) receptor 1	9446	-0.044	0.0686	No
81	PDXK	PDXK StanfordSource, GeneCards	pyridoxal (pyridoxine, vitamin B6) kinase	9527	-0.047	0.0665	No
82	PTTG1IP	PTTG1IP StanfordSource, GeneCards	pituitary tumor-transforming 1 interacting protein	9596	-0.049	0.0653	No
83	BACE2	BACE2 StanfordSource, GeneCards	beta-site APP-cleaving enzyme 2	9902	-0.058	0.0489	No
84	TMEM1	TMEM1 StanfordSource, GeneCards	transmembrane protein 1	9966	-0.060	0.0488	No
85	DNMT3L	DNMT3L StanfordSource, GeneCards	DNA (cytosine-5-)-methyltransferase 3-like	10026	-0.062	0.0491	No
86	KIAA0179	KIAA0179 StanfordSource, GeneCards	KIAA0179	10681	-0.083	0.0111	No
87	H2BFS	H2BFS StanfordSource, GeneCards	H2B histone family, member S	11390	-0.107	-0.0289	No
88	MX1	MX1 StanfordSource, GeneCards	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	11665	-0.117	-0.0391	No
89	U2AF1	U2AF1 StanfordSource, GeneCards	U2(RNU2) small nuclear RNA auxiliary factor 1	11954	-0.128	-0.0496	No
90	LRRC3	LRRC3 StanfordSource, GeneCards	leucine rich repeat containing 3	12031	-0.131	-0.0457	No
91	SON	SON StanfordSource, GeneCards	SON DNA binding protein	12149	-0.135	-0.0442	No
92	ATP5O	ATP5O StanfordSource, GeneCards	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)	12394	-0.145	-0.0504	No
93	SLC37A1	SLC37A1 StanfordSource, GeneCards	solute carrier family 37 (glycerol-3-phosphate transporter), member 1	12404	-0.146	-0.0410	No
94	PCBP3	PCBP3 StanfordSource, GeneCards	poly(rC) binding protein 3	12888	-0.167	-0.0617	No
95	TFF3	TFF3 StanfordSource, GeneCards	trefoil factor 3 (intestinal)	13271	-0.186	-0.0744	No
96	GART	GART StanfordSource, GeneCards	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	13282	-0.187	-0.0622	No
97	C21orf4	C21orf4 StanfordSource, GeneCards	chromosome 21 open reading frame 4	13525	-0.202	-0.0644	No
98	PKNOX1	PKNOX1 StanfordSource, GeneCards	PBX/knotted 1 homeobox 1	13556	-0.204	-0.0523	No
99	UBASH3A	UBASH3A StanfordSource, GeneCards	ubiquitin associated and SH3 domain containing, A	13580	-0.206	-0.0396	No
100	IL10RB	IL10RB StanfordSource, GeneCards	interleukin 10 receptor, beta	13696	-0.213	-0.0326	No
101	CBR3	CBR3 StanfordSource, GeneCards	carbonyl reductase 3	13711	-0.214	-0.0188	No
102	FTCD	FTCD StanfordSource, GeneCards	formiminotransferase cyclodeaminase	13978	-0.235	-0.0203	No
103	DSCR4	DSCR4 StanfordSource, GeneCards	Down syndrome critical region gene 4	14141	-0.247	-0.0141	No
104	SIM2	SIM2 StanfordSource, GeneCards	single-minded homolog 2 (Drosophila)	14461	-0.283	-0.0159	No
105	DSCR2	DSCR2 StanfordSource, GeneCards	Down syndrome critical region gene 2	14561	-0.297	-0.0020	No
106	ERG	ERG StanfordSource, GeneCards	v-ets erythroblastosis virus E26 oncogene like (avian)	15034	-0.506	0.0014	No