Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Gender_collapsed.gct |
| Phenotype | MALE |
| GeneSet | C2.symbols.gmt#KRAS_TOP100_KNOCKDOWN |
| Enrichment Score (ES) | 0.3518396 |
| Normalized Enrichment Score (NES) | 1.326921 |
| Nominal p-value | 0.09911243 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.951 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RES | CORE_ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IGFBP7 | IGFBP7 StanfordSource, GeneCards | insulin-like growth factor binding protein 7 | 272 | 0.385 | 0.0159 | Yes |
| 2 | BMP1 | BMP1 StanfordSource, GeneCards | bone morphogenetic protein 1 | 356 | 0.365 | 0.0427 | Yes |
| 3 | C1S | C1S StanfordSource, GeneCards | complement component 1, s subcomponent | 473 | 0.341 | 0.0651 | Yes |
| 4 | MYL9 | MYL9 StanfordSource, GeneCards | myosin, light polypeptide 9, regulatory | 479 | 0.340 | 0.0949 | Yes |
| 5 | NALP1 | NALP1 StanfordSource, GeneCards | NACHT, leucine rich repeat and PYD containing 1 | 568 | 0.325 | 0.1178 | Yes |
| 6 | FLRT2 | FLRT2 StanfordSource, GeneCards | fibronectin leucine rich transmembrane protein 2 | 680 | 0.308 | 0.1376 | Yes |
| 7 | NCF2 | NCF2 StanfordSource, GeneCards | neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) | 1104 | 0.265 | 0.1328 | Yes |
| 8 | COL4A2 | COL4A2 StanfordSource, GeneCards | collagen, type IV, alpha 2 | 1109 | 0.264 | 0.1559 | Yes |
| 9 | CCL2 | CCL2 StanfordSource, GeneCards | chemokine (C-C motif) ligand 2 | 1140 | 0.261 | 0.1770 | Yes |
| 10 | ITGAV | ITGAV StanfordSource, GeneCards | integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | 1184 | 0.256 | 0.1968 | Yes |
| 11 | MATN2 | MATN2 StanfordSource, GeneCards | matrilin 2 | 1273 | 0.249 | 0.2130 | Yes |
| 12 | ULK1 | ULK1 StanfordSource, GeneCards | unc-51-like kinase 1 (C. elegans) | 1438 | 0.237 | 0.2230 | Yes |
| 13 | CMKOR1 | CMKOR1 StanfordSource, GeneCards | chemokine orphan receptor 1 | 1486 | 0.234 | 0.2405 | Yes |
| 14 | COL5A1 | COL5A1 StanfordSource, GeneCards | collagen, type V, alpha 1 | 1686 | 0.222 | 0.2468 | Yes |
| 15 | ACVR1B | ACVR1B StanfordSource, GeneCards | activin A receptor, type IB | 1881 | 0.210 | 0.2525 | Yes |
| 16 | BHLHB2 | BHLHB2 StanfordSource, GeneCards | basic helix-loop-helix domain containing, class B, 2 | 1957 | 0.206 | 0.2657 | Yes |
| 17 | INPP4B | INPP4B StanfordSource, GeneCards | inositol polyphosphate-4-phosphatase, type II, 105kDa | 2148 | 0.196 | 0.2704 | Yes |
| 18 | KIAA0992 | KIAA0992 StanfordSource, GeneCards | palladin | 2258 | 0.192 | 0.2801 | Yes |
| 19 | CALD1 | CALD1 StanfordSource, GeneCards | caldesmon 1 | 2275 | 0.191 | 0.2959 | Yes |
| 20 | LAMP2 | LAMP2 StanfordSource, GeneCards | lysosomal-associated membrane protein 2 | 2281 | 0.190 | 0.3125 | Yes |
| 21 | TIMP3 | TIMP3 StanfordSource, GeneCards | tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 2352 | 0.187 | 0.3243 | Yes |
| 22 | PGLS | PGLS StanfordSource, GeneCards | 6-phosphogluconolactonase | 2526 | 0.178 | 0.3285 | Yes |
| 23 | ADCY7 | ADCY7 StanfordSource, GeneCards | adenylate cyclase 7 | 2636 | 0.174 | 0.3366 | Yes |
| 24 | CDH4 | CDH4 StanfordSource, GeneCards | cadherin 4, type 1, R-cadherin (retinal) | 2730 | 0.170 | 0.3455 | Yes |
| 25 | SERPINE2 | SERPINE2 StanfordSource, GeneCards | serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 3316 | 0.145 | 0.3192 | Yes |
| 26 | TGFB2 | TGFB2 StanfordSource, GeneCards | transforming growth factor, beta 2 | 3326 | 0.145 | 0.3314 | Yes |
| 27 | SGK | SGK StanfordSource, GeneCards | serum/glucocorticoid regulated kinase | 3356 | 0.143 | 0.3421 | Yes |
| 28 | SLC22A5 | SLC22A5 StanfordSource, GeneCards | solute carrier family 22 (organic cation transporter), member 5 | 3399 | 0.141 | 0.3518 | Yes |
| 29 | SLC16A4 | SLC16A4 StanfordSource, GeneCards | solute carrier family 16 (monocarboxylic acid transporters), member 4 | 3675 | 0.131 | 0.3450 | No |
| 30 | JUN | JUN StanfordSource, GeneCards | v-jun sarcoma virus 17 oncogene homolog (avian) | 3777 | 0.127 | 0.3495 | No |
| 31 | MAP3K8 | MAP3K8 StanfordSource, GeneCards | mitogen-activated protein kinase kinase kinase 8 | 4539 | 0.100 | 0.3075 | No |
| 32 | LBH | LBH StanfordSource, GeneCards | likely ortholog of mouse limb-bud and heart gene | 4679 | 0.096 | 0.3067 | No |
| 33 | ECE1 | ECE1 StanfordSource, GeneCards | endothelin converting enzyme 1 | 4731 | 0.094 | 0.3116 | No |
| 34 | CHST3 | CHST3 StanfordSource, GeneCards | carbohydrate (chondroitin 6) sulfotransferase 3 | 4862 | 0.090 | 0.3109 | No |
| 35 | TNS | TNS StanfordSource, GeneCards | tensin | 5114 | 0.082 | 0.3014 | No |
| 36 | TMEPAI | TMEPAI StanfordSource, GeneCards | transmembrane, prostate androgen induced RNA | 5149 | 0.081 | 0.3063 | No |
| 37 | SERPINE1 | SERPINE1 StanfordSource, GeneCards | serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 5230 | 0.079 | 0.3079 | No |
| 38 | DKFZp434P162 | DKFZp434P162 StanfordSource, GeneCards | hypothetical protein DKFZp434P162 | 5576 | 0.067 | 0.2908 | No |
| 39 | DICER1 | DICER1 StanfordSource, GeneCards | Dicer1, Dcr-1 homolog (Drosophila) | 5595 | 0.066 | 0.2955 | No |
| 40 | HSPB1 | HSPB1 StanfordSource, GeneCards | heat shock 27kDa protein 1 | 5719 | 0.062 | 0.2928 | No |
| 41 | WISP2 | WISP2 StanfordSource, GeneCards | WNT1 inducible signaling pathway protein 2 | 5923 | 0.057 | 0.2843 | No |
| 42 | P4HA2 | P4HA2 StanfordSource, GeneCards | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II | 5998 | 0.055 | 0.2842 | No |
| 43 | CGI-116 | CGI-116 StanfordSource, GeneCards | CGI-116 protein | 6268 | 0.047 | 0.2704 | No |
| 44 | TAGLN | TAGLN StanfordSource, GeneCards | transgelin | 6394 | 0.044 | 0.2660 | No |
| 45 | TUFT1 | TUFT1 StanfordSource, GeneCards | tuftelin 1 | 6412 | 0.043 | 0.2687 | No |
| 46 | PLEKHC1 | PLEKHC1 StanfordSource, GeneCards | pleckstrin homology domain containing, family C (with FERM domain) member 1 | 6435 | 0.043 | 0.2710 | No |
| 47 | TPM1 | TPM1 StanfordSource, GeneCards | tropomyosin 1 (alpha) | 6822 | 0.031 | 0.2480 | No |
| 48 | EVL | EVL StanfordSource, GeneCards | Enah/Vasp-like | 6906 | 0.029 | 0.2449 | No |
| 49 | IGSF4 | IGSF4 StanfordSource, GeneCards | immunoglobulin superfamily, member 4 | 6957 | 0.027 | 0.2440 | No |
| 50 | DFNA5 | DFNA5 StanfordSource, GeneCards | deafness, autosomal dominant 5 | 6969 | 0.027 | 0.2457 | No |
| 51 | ARK5 | ARK5 StanfordSource, GeneCards | KIAA0537 gene product | 7260 | 0.018 | 0.2280 | No |
| 52 | HGD | HGD StanfordSource, GeneCards | homogentisate 1,2-dioxygenase (homogentisate oxidase) | 7314 | 0.016 | 0.2259 | No |
| 53 | DKK3 | DKK3 StanfordSource, GeneCards | dickkopf homolog 3 (Xenopus laevis) | 7554 | 0.010 | 0.2108 | No |
| 54 | ST5 | ST5 StanfordSource, GeneCards | suppression of tumorigenicity 5 | 7555 | 0.010 | 0.2116 | No |
| 55 | SNAI1 | SNAI1 StanfordSource, GeneCards | snail homolog 1 (Drosophila) | 7731 | 0.004 | 0.2002 | No |
| 56 | ADAM19 | ADAM19 StanfordSource, GeneCards | a disintegrin and metalloproteinase domain 19 (meltrin beta) | 7888 | -0.001 | 0.1899 | No |
| 57 | GADD45B | GADD45B StanfordSource, GeneCards | growth arrest and DNA-damage-inducible, beta | 8133 | -0.007 | 0.1743 | No |
| 58 | JUNB | JUNB StanfordSource, GeneCards | jun B proto-oncogene | 8165 | -0.008 | 0.1729 | No |
| 59 | ATP2B4 | ATP2B4 StanfordSource, GeneCards | ATPase, Ca++ transporting, plasma membrane 4 | 8206 | -0.009 | 0.1711 | No |
| 60 | JAK1 | JAK1 StanfordSource, GeneCards | Janus kinase 1 (a protein tyrosine kinase) | 9031 | -0.032 | 0.1189 | No |
| 61 | MGEA5 | MGEA5 StanfordSource, GeneCards | meningioma expressed antigen 5 (hyaluronidase) | 9308 | -0.039 | 0.1039 | No |
| 62 | PDXK | PDXK StanfordSource, GeneCards | pyridoxal (pyridoxine, vitamin B6) kinase | 9527 | -0.047 | 0.0935 | No |
| 63 | COL4A1 | COL4A1 StanfordSource, GeneCards | collagen, type IV, alpha 1 | 9899 | -0.058 | 0.0738 | No |
| 64 | TGFBI | TGFBI StanfordSource, GeneCards | transforming growth factor, beta-induced, 68kDa | 9990 | -0.060 | 0.0731 | No |
| 65 | GPR56 | GPR56 StanfordSource, GeneCards | G protein-coupled receptor 56 | 10144 | -0.065 | 0.0687 | No |
| 66 | COL7A1 | COL7A1 StanfordSource, GeneCards | collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) | 10206 | -0.067 | 0.0705 | No |
| 67 | MUC3B | MUC3B StanfordSource, GeneCards | mucin 3B | 10290 | -0.070 | 0.0711 | No |
| 68 | RSU1 | RSU1 StanfordSource, GeneCards | Ras suppressor protein 1 | 10460 | -0.076 | 0.0665 | No |
| 69 | GABARAPL1 | GABARAPL1 StanfordSource, GeneCards | GABA(A) receptor-associated protein like 1 | 10563 | -0.079 | 0.0667 | No |
| 70 | EPHB2 | EPHB2 StanfordSource, GeneCards | EphB2 | 10656 | -0.082 | 0.0678 | No |
| 71 | HSPG2 | HSPG2 StanfordSource, GeneCards | heparan sulfate proteoglycan 2 (perlecan) | 10959 | -0.092 | 0.0557 | No |
| 72 | CLDN4 | CLDN4 StanfordSource, GeneCards | claudin 4 | 11749 | -0.120 | 0.0136 | No |
| 73 | MSC | MSC StanfordSource, GeneCards | musculin (activated B-cell factor-1) | 11912 | -0.126 | 0.0139 | No |
| 74 | SOX4 | SOX4 StanfordSource, GeneCards | SRY (sex determining region Y)-box 4 | 11926 | -0.127 | 0.0243 | No |
| 75 | NCK2 | NCK2 StanfordSource, GeneCards | NCK adaptor protein 2 | 12092 | -0.133 | 0.0250 | No |
| 76 | WASPIP | WASPIP StanfordSource, GeneCards | Wiskott-Aldrich syndrome protein interacting protein | 12214 | -0.138 | 0.0291 | No |
| 77 | SPARC | SPARC StanfordSource, GeneCards | secreted protein, acidic, cysteine-rich (osteonectin) | 12626 | -0.155 | 0.0154 | No |
| 78 | DNAJB2 | DNAJB2 StanfordSource, GeneCards | DnaJ (Hsp40) homolog, subfamily B, member 2 | 12698 | -0.158 | 0.0246 | No |
| 79 | SPOCK | SPOCK StanfordSource, GeneCards | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) | 12829 | -0.164 | 0.0304 | No |
| 80 | IGFBP3 | IGFBP3 StanfordSource, GeneCards | insulin-like growth factor binding protein 3 | 13917 | -0.230 | -0.0218 | No |
| 81 | C8orf4 | C8orf4 StanfordSource, GeneCards | chromosome 8 open reading frame 4 | 14063 | -0.241 | -0.0102 | No |
| 82 | GLIPR1 | GLIPR1 StanfordSource, GeneCards | GLI pathogenesis-related 1 (glioma) | 14256 | -0.258 | -0.0001 | No |
| 83 | COL1A1 | COL1A1 StanfordSource, GeneCards | collagen, type I, alpha 1 | 14489 | -0.286 | 0.0097 | No |
| 84 | NPTX1 | NPTX1 StanfordSource, GeneCards | neuronal pentraxin I | 14667 | -0.317 | 0.0259 | No |
