Gene Set: ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP

Standard name

ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP

Systematic name

M2570

Brief description

Genes up-regulated during prostate cancer progression in the JOCK1 model due to inducible activation of FGFR1 [GeneID=2260] gene in prostate.

Full description or abstract

Fibroblast Growth Factor Receptor-1 (FGFR1) is commonly overexpressed in advanced prostate cancer (PCa). To investigate causality, we utilized an inducible FGFR1 (iFGFR1) prostate mouse model. Activation of iFGFR1 with chemical inducers of dimerization (CID) led to highly synchronous, step-wise progression to adenocarcinoma that is linked to an epithelial-to-mesenchymal transition (EMT). iFGFR1 inactivation by CID withdrawal led to full reversion of prostatic intraepithelial neoplasia, whereas PCa lesions became iFGFR1-independent. Gene expression profiling at distinct stages of tumor progression revealed an increase in EMT-associated Sox9 and changes in the Wnt signaling pathway, including Fzd4, which was validated in human PCa. The iFGFR1 model clearly implicates FGFR1 in PCa progression and demonstrates how CID-inducible models can help evaluate candidate molecules in tumor progression and maintenance.

Collection

ARCHIVED: Archived Founder gene sets that are referenced by current Hallmarks
C2_CGP: Archived chemical and genetic perturbations

Source publication

Pubmed 18068632 Authors: Acevedo VD,Gangula RD,Freeman KW,Li R,Zhang Y,Wang F,Ayala GE,Peterson LE,Ittmann M,Spencer DM

Exact source

Table 1S: Avg. fold change > 1

Related gene sets

(show 1 additional gene sets from the source publication)

(show 94 gene sets from the same authors)

External links

Filtered by similarity

Organism

Mus musculus

Contributed by

Yujin Hoshida (Broad Institute)

Source platform

UniGene_ID

Dataset references

(show 1 datasets)

Download gene set

format: grp | text | gmt | gmx | xml

Compute overlaps

Compendia expression profiles

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Gene families

Show members

(show 333 members mapped to 0 genes)

Original Member	NCBI (Entrez) Gene Id	Gene Symbol	Gene Description
Mm.100895
Mm.10091
Mm.102752
Mm.103545
Mm.105324
Mm.10545
Mm.1068
Mm.116683
Mm.117896
Mm.1192
Mm.119320
Mm.120271
Mm.125754
Mm.126193
Mm.12638
Mm.12723
Mm.1286
Mm.12900
Mm.130793
Mm.1311
Mm.131665
Mm.132299
Mm.133037
Mm.13445
Mm.135072
Mm.1359
Mm.137
Mm.137467
Mm.13787
Mm.138039
Mm.140154
Mm.140158
Mm.141741
Mm.1451
Mm.14543
Mm.14627
Mm.1500
Mm.1508
Mm.154045
Mm.154144
Mm.15691
Mm.1583
Mm.1614
Mm.1650
Mm.16773
Mm.170276
Mm.171256
Mm.171335
Mm.1791
Mm.17917
Mm.180157
Mm.181050
Mm.18626
Mm.188499
Mm.191949
Mm.19320
Mm.196290
Mm.19844
Mm.200608
Mm.204765
Mm.205854
Mm.206505
Mm.206919
Mm.207971
Mm.208445
Mm.20944
Mm.21013
Mm.210465
Mm.2108
Mm.212742
Mm.212812
Mm.213417
Mm.214682
Mm.217323
Mm.217362
Mm.21855
Mm.221271
Mm.22270
Mm.22650
Mm.228
Mm.228363
Mm.230249
Mm.23242
Mm.233951
Mm.234965
Mm.23526
Mm.235527
Mm.23575
Mm.237772
Mm.237985
Mm.2380
Mm.23942
Mm.239941
Mm.24006
Mm.241056
Mm.241073
Mm.24248
Mm.24337
Mm.244078
Mm.244403
Mm.246009
Mm.246497
Mm.246512
Mm.24684
Mm.247121
Mm.247143
Mm.247564
Mm.247695
Mm.248615
Mm.249297
Mm.249873
Mm.250392
Mm.251288
Mm.25138
Mm.252145
Mm.252210
Mm.252339
Mm.252385
Mm.252879
Mm.253601
Mm.25405
Mm.254297
Mm.2543
Mm.25479
Mm.2553
Mm.255848
Mm.256718
Mm.25775
Mm.258484
Mm.258893
Mm.259072
Mm.259702
Mm.259929
Mm.260056
Mm.261453
Mm.262037
Mm.262053
Mm.263124
Mm.263708
Mm.265985
Mm.26632
Mm.267131
Mm.268547
Mm.268618
Mm.269426
Mm.271572
Mm.272025
Mm.27227
Mm.27254
Mm.272646
Mm.27289
Mm.272955
Mm.273285
Mm.27369
Mm.274366
Mm.274376
Mm.274466
Mm.274948
Mm.274956
Mm.274981
Mm.275036
Mm.275233
Mm.276736
Mm.278922
Mm.279310
Mm.280038
Mm.280069
Mm.280103
Mm.280211
Mm.28038
Mm.280641
Mm.281011
Mm.282386
Mm.282672
Mm.284033
Mm.28518
Mm.286407
Mm.286495
Mm.28683
Mm.287187
Mm.28756
Mm.288474
Mm.288669
Mm.288898
Mm.289377
Mm.289590
Mm.289747
Mm.290421
Mm.290563
Mm.290837
Mm.29274
Mm.292834
Mm.293200
Mm.29357
Mm.293574
Mm.29586
Mm.296453
Mm.29739
Mm.29847
Mm.29938
Mm.2999
Mm.299952
Mm.30010
Mm.30262
Mm.30504
Mm.30756
Mm.308089
Mm.31376
Mm.314
Mm.31486
Mm.315011
Mm.3152
Mm.31626
Mm.316391
Mm.31672
Mm.317947
Mm.31852
Mm.32068
Mm.32563
Mm.326911
Mm.330428
Mm.330986
Mm.331191
Mm.33192
Mm.33240
Mm.332550
Mm.332931
Mm.333124
Mm.3333
Mm.33402
Mm.33403
Mm.334041
Mm.335657
Mm.33574
Mm.337113
Mm.33874
Mm.338790
Mm.340702
Mm.343607
Mm.34441
Mm.3468
Mm.348025
Mm.35605
Mm.356096
Mm.356496
Mm.359802
Mm.360986
Mm.362054
Mm.369343
Mm.370175
Mm.371570
Mm.371611
Mm.373589
Mm.373976
Mm.374824
Mm.37558
Mm.376584
Mm.379147
Mm.379155
Mm.379209
Mm.379443
Mm.379500
Mm.38049
Mm.380756
Mm.3820
Mm.383252
Mm.386750
Mm.386756
Mm.386786
Mm.38884
Mm.38909
Mm.38948
Mm.3994
Mm.4081
Mm.41209
Mm.41236
Mm.4132
Mm.4154
Mm.4159
Mm.41604
Mm.4168
Mm.4189
Mm.42029
Mm.42135
Mm.42956
Mm.44235
Mm.4502
Mm.45372
Mm.45995
Mm.4610
Mm.46386
Mm.4641
Mm.46425
Mm.4660
Mm.46612
Mm.4857
Mm.4933
Mm.4979
Mm.50424
Mm.5378
Mm.54166
Mm.55143
Mm.57174
Mm.57223
Mm.62886
Mm.64326
Mm.66222
Mm.66293
Mm.67073
Mm.6853
Mm.7214
Mm.77381
Mm.77895
Mm.788
Mm.81496
Mm.8245
Mm.83817
Mm.8552
Mm.86425
Mm.867
Mm.86755
Mm.87373
Mm.89961
Mm.90047
Mm.91969
Mm.9537
Mm.96996
Mm.97885
Mm.97986
Mm.9911
Mm.9916
Mm.99395
Mm.99613

Version history

3.1: First introduced

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