Gene Set: AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN

Standard name AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN
Systematic name M8897
Brief description Down-regulated genes whose expression correlates with copy number losses in pancreatic adenocarcinoma cell lines and primary tumor specimens.
Full description or abstract The pancreatic adenocarcinoma genome harbors multiple amplifications and deletions, pointing to the existence of numerous oncogenes and tumor suppressor genes driving the genesis and progression of this lethal cancer. Here, array comparative genomic hybridization on a cDNA microarray platform and informatics tools have been used to define the copy number alterations in a panel of 24 pancreatic adenocarcinoma cell lines and 13 primary tumor specimens. This high-resolution genomic analysis has identified all known regional gains and losses as well as many previously uncharacterized highly recurrent copy number alterations. A systematic prioritization scheme has selected 64 focal minimal common regions (MCRs) of recurrent copy number change. These MCRs possess a median size of 2.7 megabases (Mb), with 21 (33%) MCRs spanning 1 Mb or less (median of 0.33 Mb) and possessing an average of 15 annotated genes. Furthermore, complementary expression profile analysis of a significant fraction of the genes residing within these 64 prioritized MCRs has enabled the identification of a subset of candidates with statistically significant association between gene dosage and mRNA expression. Thus, the integration of DNA and RNA profiles provides a highly productive entry point for the discovery of genes involved in the pathogenesis of pancreatic adenocarcinoma.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15199222   Authors: Aguirre AJ,Brennan C,Bailey G,Sinha R,Feng B,Leo C,Zhang Y,Zhang J,Gans JD,Bardeesy N,Cauwels C,Cordon-Cardo C,Redston MS,DePinho RA,Chin L
Exact source Table 5S: gene weight < 0
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Organism Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform AFFY_HG_U133
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