Gene Set: AUJLA_IL22_AND_IL17A_SIGNALING

Standard name AUJLA_IL22_AND_IL17A_SIGNALING
Systematic name M6335
Brief description Genes changed in HBE cells (bronchial epithelium) after treatment with IL22 and IL17A [GeneID=50616;3605].
Full description or abstract Emerging evidence supports the concept that T helper type 17 (T(H)17) cells, in addition to mediating autoimmunity, have key roles in mucosal immunity against extracellular pathogens. Interleukin-22 (IL-22) and IL-17A are both effector cytokines produced by the T(H)17 lineage, and both were crucial for maintaining local control of the Gram-negative pulmonary pathogen, Klebsiella pneumoniae. Although both cytokines regulated CXC chemokines and granulocyte colony-stimulating factor production in the lung, only IL-22 increased lung epithelial cell proliferation and increased transepithelial resistance to injury. These data support the concept that the T(H)17 cell lineage and its effector molecules have evolved to effect host defense against extracellular pathogens at mucosal sites.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 18264110   Authors: Aujla SJ,Chan YR,Zheng M,Fei M,Askew DJ,Pociask DA,Reinhart TA,McAllister F,Edeal J,Gaus K,Husain S,Kreindler JL,Dubin PJ,Pilewski JM,Myerburg MM,Mason CA,Iwakura Y,Kolls JK
Exact source Fig. 1B
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Organism Homo sapiens
Contributed by Jessica Robertson (MSigDB Team)
Source platform HUMAN_GENE_SYMBOL
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Version history 3.0: First introduced

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