Gene Set: BASSO_B_LYMPHOCYTE_NETWORK

Standard name BASSO_B_LYMPHOCYTE_NETWORK
Systematic name M10633
Brief description Genes which comprise the top 1% of highly interconnected genes (major hubs) that account for most of gene interactions in the reconstructed regulatory networks from expression profiles in B lymphocytes.
Full description or abstract Cellular phenotypes are determined by the differential activity of networks linking coregulated genes. Available methods for the reverse engineering of such networks from genome-wide expression profiles have been successful only in the analysis of lower eukaryotes with simple genomes. Using a new method called ARACNe (algorithm for the reconstruction of accurate cellular networks), we report the reconstruction of regulatory networks from expression profiles of human B cells. The results are suggestive a hierarchical, scale-free network, where a few highly interconnected genes (hubs) account for most of the interactions. Validation of the network against available data led to the identification of MYC as a major hub, which controls a network comprising known target genes as well as new ones, which were biochemically validated. The newly identified MYC targets include some major hubs. This approach can be generally useful for the analysis of normal and pathologic networks in mammalian cells.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15778709   Authors: Basso K,Margolin AA,Stolovitzky G,Klein U,Dalla-Favera R,Califano A
Exact source Table 3S: 1% cutoff
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Organism Homo sapiens
Contributed by Jean Junior (MSigDB Team)
Source platform AFFY_HG_U95
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Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: Renamed from BASSO_REGULATORY_HUBS

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