Gene Set: BERTUCCI_INVASIVE_CARCINOMA_DUCTAL_VS_LOBULAR_DN

Standard name BERTUCCI_INVASIVE_CARCINOMA_DUCTAL_VS_LOBULAR_DN
Systematic name M14142
Brief description Genes down-regulated in the invasive ductal carcinoma (IDC) compared to the invasive lobular carcinoma (ILC), the two major pathological types of breast cancer.
Full description or abstract Invasive ductal carcinomas (IDCs) and invasive lobular carcinomas (ILCs) are the two major pathological types of breast cancer. Epidemiological and histoclinical data suggest biological differences, but little is known about the molecular alterations involved in ILCs. We undertook a comparative large-scale study by both array-compared genomic hybridization and cDNA microarray of a set of 50 breast tumors (21 classic ILCs and 29 IDCs) selected on homogeneous histoclinical criteria. Results were validated on independent tumor sets, as well as by quantitative RT-PCR. ILCs and IDCs presented differences at both the genomic and expression levels with ILCs being less rearranged and heterogeneous than IDCs. Supervised analysis defined a 75-BACs signature discriminating accurately ILCs from IDCs. Expression profiles identified two subgroups of ILCs: typical ILCs ( approximately 50%), which were homogeneous and displayed a normal-like molecular pattern, and atypical ILCs, more heterogeneous with features intermediate between ILCs and IDCs. Supervised analysis identified a 75-gene expression signature that discriminated ILCs from IDCs, with many genes involved in cell adhesion, motility, apoptosis, protein folding, extracellular matrix and protein phosphorylation. Although ILCs and IDCs share common alterations, our data show that ILCs and IDCs could be distinguished on the basis of their genomic and expression profiles suggesting that they evolve along distinct genetic pathways.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 18490921   Authors: Bertucci F,Orsetti B,Nègre V,Finetti P,Rougé C,Ahomadegbe JC,Bibeau F,Mathieu MC,Treilleux I,Jacquemier J,Ursule L,Martinec A,Wang Q,Bénard J,Puisieux A,Birnbaum D,Theillet C
Exact source Table 3: Status=UP LOB
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Organism Homo sapiens
Contributed by Jessica Robertson (MSigDB Team)
Source platform HUMAN_SEQ_ACCESSION
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Version history 3.0: First introduced

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