Gene Set: DER_IFN_BETA_RESPONSE_UP

Standard name DER_IFN_BETA_RESPONSE_UP
Systematic name M13453
Brief description Genes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon beta for 6 h.
Full description or abstract The pleiotropic activities of interferons (IFNs) are mediated primarily through the transcriptional regulation of many downstream effector genes. The mRNA profiles from IFN-alpha, -beta, or -gamma treatments of the human fibrosarcoma cell line, HT1080, were determined by using oligonucleotide arrays with probe sets corresponding to more than 6,800 human genes. Among these were transcripts for known IFN-stimulated genes (ISGs), the expression of which were consistent with previous studies in which the particular ISG was characterized as responsive to either Type I (alpha, beta) or Type II (gamma) IFNs, or both. Importantly, many novel IFN-stimulated genes were identified that were diverse in their known biological functions. For instance, several novel ISGs were identified that are implicated in apoptosis (including RAP46/Bag-1, phospholipid scramblase, and hypoxia inducible factor-1alpha). Furthermore, several IFN-repressed genes also were identified. These results demonstrate the usefulness of oligonucleotide arrays in monitoring mammalian gene expression on a broad and unprecedented scale. In particular, these findings provide insights into the basic mechanisms of IFN actions and ultimately may contribute to better therapeutic uses for IFNs.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 9861020   Authors: Der SD,Zhou A,Williams BR,Silverman RH
Exact source Table 2: IFN beta
Related gene sets (show 5 additional gene sets from the source publication)

(show 6 gene sets from the same authors)
External links  
Organism Homo sapiens
Contributed by Yujin Hoshida (Broad Institute)
Source platform Hu6800
Dataset references  
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 103 genes
Gene families Categorize these 103 genes by gene family
Show members (show 108 members mapped to 103 genes)
Version history 3.0: Renamed from DER_IFNB_UP

See MSigDB license terms here. Please note that certain gene sets have special access terms.