Gene Set: ELLWOOD_MYC_TARGETS_UP

Standard name ELLWOOD_MYC_TARGETS_UP
Systematic name M2607
Brief description Genes up-regulated in transgenic mice expressing human MYC [GeneID=4609] in prostate.
Full description or abstract Increased Myc gene copy number is observed in human prostate cancer. To define Myc's functional role, we generated transgenic mice expressing human c-Myc in the mouse prostate. All mice developed murine prostatic intraepithelial neoplasia followed by invasive adenocarcinoma. Microarray-based expression profiling identified a Myc prostate cancer expression signature, which included the putative human tumor suppressor NXK3.1. Human prostate tumor databases revealed modules of human genes that varied in concert with the Myc prostate cancer signature. This module includes the Pim-1 kinase, a gene known to cooperate with Myc in tumorigenesis, and defines a subset of human, Myc-like human cancers. This approach illustrates how genomic technologies can be applied to mouse cancer models to guide evaluation of human tumor databases.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 14522256   Authors: Ellwood-Yen K,Graeber TG,Wongvipat J,Iruela-Arispe ML,Zhang J,Matusik R,Thomas GV,Sawyers CL
Exact source Table 1S: rank <= 60, direction = up
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Organism Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
Source platform AFFY_MG_U74
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