Human Gene Set: ERBB2_UP.V1_DN

Standard name ERBB2_UP.V1_DN
Systematic name M2635
Brief description Genes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 [GeneID=2099] and engineered to express ligand-activatable ERBB2 [GeneID=2064].
Full description or abstract Profiling of MCF-7 cell lines stably overexpressing constitutively active c-erbB-2 as well as control vector transfected cells (coMCF-7) and control vector transfected cells long-term adapted for estrogen-independent growth (coMCF-7/lt-E2).
Collection C6: Oncogenic Signature
Source publication Pubmed 16585219   Authors: Creighton CJ,Hilger AM,Murthy S,Rae JM,Chinnaiyan AM,El-Ashry D
Exact source c-erbB-2 vs control; bottom 200 genes
Related gene sets (show 9 additional gene sets from the source publication)

(show 26 gene sets from the same authors)
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Source species Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
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Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 7.0: Renamed from ERB2_UP.V1_DN

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