Gene Set: FALVELLA_SMOKERS_WITH_LUNG_CANCER

Standard name FALVELLA_SMOKERS_WITH_LUNG_CANCER
Systematic name M18536
Brief description Genes that distinguish normal from cancer (lung adenocarcinoma) samples and smokers from non-smoking subjects.
Full description or abstract Evidence in animal models has suggested an association between susceptibility to lung tumorigenesis and gene-expression profiles in normal lung. Here, we compared RNA pools from normal lung tissue of lung adenocarcinoma patients (cases) or non-lung cancer patients (controls) by hybridization of whole-human genome expression arrays. Principal component analysis identified a gene-expression signature of 85 genes that distinguishes cases from controls as well as smokers from nonsmokers. Elevated mRNA levels of one of these genes, AZGP1, were significantly associated with disease status. These results support the hypothesis that differences in the gene-expression levels of the normal tissue may be predictive of genetic predisposition to lung cancer in humans.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 17724461   Authors: Falvella FS,Spinola M,Pignatiello C,Noci S,Conti B,Pastorino U,Carbone A,Dragani TA
Exact source Table 2
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Organism Homo sapiens
Contributed by Jessica Robertson (MSigDB Team)
Source platform HUMAN_GENE_SYMBOL
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Version history 3.0: First introduced

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