Gene Set: FINAK_BREAST_CANCER_SDPP_SIGNATURE

Standard name FINAK_BREAST_CANCER_SDPP_SIGNATURE
Systematic name M12461
Brief description Genes in the stroma-derived prognostic predictor of breast cancer disease outcome.
Full description or abstract Although it is increasingly evident that cancer is influenced by signals emanating from tumor stroma, little is known regarding how changes in stromal gene expression affect epithelial tumor progression. We used laser capture microdissection to compare gene expression profiles of tumor stroma from 53 primary breast tumors and derived signatures strongly associated with clinical outcome. We present a new stroma-derived prognostic predictor (SDPP) that stratifies disease outcome independently of standard clinical prognostic factors and published expression-based predictors. The SDPP predicts outcome in several published whole tumor-derived expression data sets, identifies poor-outcome individuals from multiple clinical subtypes, including lymph node-negative tumors, and shows increased accuracy with respect to previously published predictors, especially for HER2-positive tumors. Prognostic power increases substantially when the predictor is combined with existing outcome predictors. Genes represented in the SDPP reveal the strong prognostic capacity of differential immune responses as well as angiogenic and hypoxic responses, highlighting the importance of stromal biology in tumor progression.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 18438415   Authors: Finak G,Bertos N,Pepin F,Sadekova S,Souleimanova M,Zhao H,Chen H,Omeroglu G,Meterissian S,Omeroglu A,Hallett M,Park M
Exact source Table 2
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Organism Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform HUMAN_GENE_SYMBOL
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Version history 3.0: First introduced

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