Gene Set: GENTLES_LEUKEMIC_STEM_CELL_DN

Standard name GENTLES_LEUKEMIC_STEM_CELL_DN
Systematic name M2543
Brief description Genes down-regulated in LSC (leukemic stem) cells compared to LPC (leukemia progenitor) cells from AML (acute myeloid leukemia) tumor samples.
Full description or abstract In many cancers, specific subpopulations of cells appear to be uniquely capable of initiating and maintaining tumors. The strongest support for this cancer stem cell model comes from transplantation assays in immunodeficient mice, which indicate that human acute myeloid leukemia (AML) is driven by self-renewing leukemic stem cells (LSCs). This model has significant implications for the development of novel therapies, but its clinical relevance has yet to be determined.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 21177505   Authors: Gentles AJ,Plevritis SK,Majeti R,Alizadeh AA
Exact source Table 2S: Mean FC < 0 (green)
Related gene sets (show 1 additional gene sets from the source publication)

(show 8 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Andrew Gentles (Stanford University)
Source platform Human_RefSeq
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Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.1: First introduced

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