Systematic name M2386
Brief description Top genes down-regulated in metastatic (T24T) vs non-metastatic (T24) bladder cancer cell lines.
Full description or abstract To discover novel metastasis suppressor genes that are clinically relevant in common human cancers, we used isogenic human bladder cancer cell lines and used DNA microarray technology to identify genes whose expression diminishes as a function of invasive and metastatic competence. We then evaluated the expression profile of such genes in 105 pathologically characterized tumors from seven common organ sites, and we identified one gene, RhoGDI2, whose expression was diminished as a function of primary tumor stage and grade. When RhoGDI2 was transferred back into cells with metastatic ability that lacked its expression, it suppressed experimental lung metastasis but did not affect in vitro growth, colony formation, or in vivo tumorigenicity. In addition, RhoGDI2 reconstitution in these cells blocked invasion in an organotypic assay and led to a reduction of in vitro motility. These results indicate that RhoGDI2 is a metastasis suppressor gene, a marker of aggressive human cancer, and a promising target for therapy.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 12438227   Authors: Gildea JJ,Seraj MJ,Oxford G,Harding MA,Hampton GM,Moskaluk CA,Frierson HF,Conaway MR,Theodorescu D
Exact source Table 1
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Organism Homo sapiens
Contributed by Kevin Vogelsang (MSigDB Team)
Source platform AFFY_HG_U133
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NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: Renamed from GILDEA_BLADDER_UP

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