Gene Set: GOLDRATH_HOMEOSTATIC_PROLIFERATION

Standard name GOLDRATH_HOMEOSTATIC_PROLIFERATION
Systematic name M3592
Brief description Up-regulated in CD8+ [GeneID=925] T lymphocytes undergoing homeostatic proliferation (HP) versus the naive cells; these genes are not up-regulated versus effector or memory cell population.
Full description or abstract Naive T cells proliferate independently of cognate antigen when introduced into lymphopenic hosts. Lymphopenia-induced proliferation depends on low-affinity MHC/self-peptide complexes and on IL-7. To elucidate the intracellular signals mediating this proliferation, we analyzed changes in gene expression in naive CD8+ T cells at different times after their transfer into a lymphopenic environment. The genes induced in response to lymphopenia were largely an attenuated subset of those turned up by full antigenic stimulation, including genes related to cell cycling, whereas excluding genes specifically associated with effector activity. After the initial phase of proliferation in an empty compartment, the naive T cells adopted a stable pattern of gene expression similar to that of antigen-experienced memory cells. Thus, T cells proliferating in lymphopenic hosts do not exhibit a unique gene-expression profile, instead relying on traditional signals for this antigen-independent proliferation; this process ultimately results in differentiation to authentic memory cells.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15548615   Authors: Goldrath AW,Luckey CJ,Park R,Benoist C,Mathis D
Exact source Table 5S
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Organism Mus musculus
Contributed by Kate Stafford (MSigDB Team)
Source platform AFFY_MG_U74
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Version history 3.0: Renamed from GOLDRATH_HP

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