Gene Set: GOLDRATH_IMMUNE_MEMORY

Standard name GOLDRATH_IMMUNE_MEMORY
Systematic name M10845
Brief description 'Memory genes' expressed uniquely in CD8+ [GeneID=925] memory T lymphocytes (compared with effector or naive cells)
Full description or abstract Naive T cells proliferate independently of cognate antigen when introduced into lymphopenic hosts. Lymphopenia-induced proliferation depends on low-affinity MHC/self-peptide complexes and on IL-7. To elucidate the intracellular signals mediating this proliferation, we analyzed changes in gene expression in naive CD8+ T cells at different times after their transfer into a lymphopenic environment. The genes induced in response to lymphopenia were largely an attenuated subset of those turned up by full antigenic stimulation, including genes related to cell cycling, whereas excluding genes specifically associated with effector activity. After the initial phase of proliferation in an empty compartment, the naive T cells adopted a stable pattern of gene expression similar to that of antigen-experienced memory cells. Thus, T cells proliferating in lymphopenic hosts do not exhibit a unique gene-expression profile, instead relying on traditional signals for this antigen-independent proliferation; this process ultimately results in differentiation to authentic memory cells.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15548615   Authors: Goldrath AW,Luckey CJ,Park R,Benoist C,Mathis D
Exact source Table 4S
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(show 313 gene sets from the same authors)
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Organism Mus musculus
Contributed by Kate Stafford (MSigDB Team)
Source platform AFFY_MG_U74
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Version history 3.0: Renamed from GOLDRATH_MEMORY

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