Gene Set: GOLUB_ALL_VS_AML_DN

Standard name GOLUB_ALL_VS_AML_DN
Systematic name M6761
Brief description Down-regulated genes highly correlated with acute lymphoblastic leukemia (ALL) vs acute myeloid leukemia (AML).
Full description or abstract Although cancer classification has improved over the past 30 years, there has been no general approach for identifying new cancer classes (class discovery) or for assigning tumors to known classes (class prediction). Here, a generic approach to cancer classification based on gene expression monitoring by DNA microarrays is described and applied to human acute leukemias as a test case. A class discovery procedure automatically discovered the distinction between acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) without previous knowledge of these classes. An automatically derived class predictor was able to determine the class of new leukemia cases. The results demonstrate the feasibility of cancer classification based solely on gene expression monitoring and suggest a general strategy for discovering and predicting cancer classes for other types of cancer, independent of previous biological knowledge.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 10521349   Authors: Golub TR,Slonim DK,Tamayo P,Huard C,Gaasenbeek M,Mesirov JP,Coller H,Loh ML,Downing JR,Caligiuri MA,Bloomfield CD,Lander ES
Exact source Fig 3b: blue in ALL
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Organism Homo sapiens
Contributed by Jean Junior (MSigDB Team)
Source platform AFFY_HuGene
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Version history 3.0: Renamed from GOLUB_ALL_VS_AML_DN

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