Gene Set: GSE10239_NAIVE_VS_MEMORY_CD8_TCELL_UP

Standard name GSE10239_NAIVE_VS_MEMORY_CD8_TCELL_UP
Systematic name M3048
Brief description Genes up-regulated in comparison of naive CD8 T cells versus memory CD8 T cells.
Full description or abstract Using killer cell lectin-like receptor G1 as a marker to distinguish terminal effector cells from memory precursors, we found that despite their diverse cell fates both subsets possessed remarkably similar gene expression profiles and functioned as equally potent killer cells. However, only the memory precursors were capable of making IL-2 thus defining a novel effector cell that was cytotoxic, expressed granzyme B, and produced inflammatory cytokines in addition to IL-2. This effector population then differentiated into long-lived protective memory T cells capable of self-renewal and rapid re-call responses. Mechanistic studies showed that cells that continued to receive antigenic stimulation during the later stages of infection were more likely to become terminal effectors. Importantly, curtailing antigenic stimulation towards the tail-end of the acute infection enhanced the generation of memory cells. These studies support the decreasing potential model of memory differentiation and show that the duration of antigenic stimulation is a critical regulator of memory formation
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 18316415   Authors: Sarkar S,Kalia V,Haining WN,Konieczny BT
Exact source GSE10239_1247_200_UP
Related gene sets (show 15 additional gene sets from the source publication)

(show 116 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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