Human Gene Set: GSE12392_CD8A_POS_VS_NEG_SPLEEN_IFNB_KO_DC_DN


Standard name GSE12392_CD8A_POS_VS_NEG_SPLEEN_IFNB_KO_DC_DN
Systematic name M7134
Brief description Genes down-regulated in splenic dendritic cells from IFNB1 [GeneID=3456] knockout mice: CD8A+ [GeneID=925] versus CD8A- [GeneID=925] populations.
Full description or abstract Type I Interferons encompasses a large family of closely related cytokines comprising of at least 13 IFN-? isotypes and single IFN-?. Both IFN-? and IFN-? exert their activity through a common receptor IFNAR. Type I Interferons have broad regulatory effects and various subtypes of dendritic cells are influenced by this cytokines. In our study we asked question whether the low, constitutive levels of type I Interferons produced under steady state conditions are important for proper function of splenic conventional dendritic cells.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 19581626   Authors: Zietara N,?yszkiewicz M,Gekara N,Pucha?ka J,Dos Santos VA,Hunt CR,Pandita TK,Lienenklaus S,Weiss S
Exact source GSE12392_2737_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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