Gene Set: GSE12392_WT_VS_IFNB_KO_CD8A_POS_SPLEEN_DC_DN

Standard name GSE12392_WT_VS_IFNB_KO_CD8A_POS_SPLEEN_DC_DN
Systematic name M7144
Brief description Genes down-regulated in CD8A+ [GeneID=925] splenic dendritic cells: wildtype versus IFNB1 [GeneID=3456] knockout mice.
Full description or abstract Type I Interferons encompasses a large family of closely related cytokines comprising of at least 13 IFN-? isotypes and single IFN-?. Both IFN-? and IFN-? exert their activity through a common receptor IFNAR. Type I Interferons have broad regulatory effects and various subtypes of dendritic cells are influenced by this cytokines. In our study we asked question whether the low, constitutive levels of type I Interferons produced under steady state conditions are important for proper function of splenic conventional dendritic cells.
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 19581626   Authors: Zietara N,?yszkiewicz M,Gekara N,Pucha?ka J,Santos Dos VA,Hunt CR,Pandita TK,Lienenklaus S,Weiss S
Exact source GSE12392_2738_200_DN
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(show 36 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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