Standard name GSE13887_RESTING_VS_ACT_CD4_TCELL_UP
Systematic name M478
Brief description Genes up-regulated in CD4 [GeneID=920] T cells from healthy donors: resting versus activated by anti-CD3 and anti-CD28.
Full description or abstract CD3-positive T cells were negatively isolated from 10 SLE patients and 9 healthy controls without SLE. All of the SLE samples and control samples were compared with one another to identify baseline differences in expression due to the disease. Next, T cell preparations from 4 of the control subjects were stimulated with either Nitric Oxide (NOC-18) 600 uM for 24hr or stimulated through CD3/CD28 for 24hr to determine which genes were responsive to these signaling mechanisms. Here, we show that activity of the mammalian target of rapamycin (mTOR), which is a sensor of the mitochondrial transmembrane potential, is increased in SLE T cells. Activation of mTOR was inducible by NO, a key trigger of MHP which in turn enhanced the expression of HRES-1/Rab4, a small GTPase that regulates recycling of surface receptors through early endosomes. Expression of HRES-1/Rab4 was increased in SLE T cells and, in accordance with its dominant impact on the endocytic recycling of CD4, it was inversely correlated with diminished CD4 expression. HRES-1/Rab4 over-expression was also inversely correlated with diminished TCR? protein levels. Combined with follow up studies, these results suggest that activation of mTOR causes the loss of TCR? in lupus T cells through HRES-1/Rab4-dependent lysosomal degradation.
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 19201859   Authors: Fernandez DR,Telarico T,Bonilla E,Li Q,Banerjee S,Middleton FA,Phillips PE,Crow MK,Oess S,Muller-Esterl W,Perl A
Exact source GSE13887_2805_200_UP
Related gene sets (show 7 additional gene sets from the source publication)

(show 33 gene sets from the same authors)
External links  
Filtered by similarity
Organism Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 108 genes
Gene families Categorize these 108 genes by gene family
Show members (show 200 members mapped to 108 genes)
Version history 7.3: Moved to ImmuneSigDB sub-collection.

See MSigDB license terms here. Please note that certain gene sets have special access terms.