Gene Set: GSE14308_TH2_VS_TH1_DN

Standard name GSE14308_TH2_VS_TH1_DN
Systematic name M3360
Brief description Genes down-regulated in comparison of Th2 cells versus Th1 cells.
Full description or abstract Multipotential naīve CD4+ T cells differentiate into distinct lineages including T helper 1 (Th1), Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4+ T cells begs the question whether the observed changes reflect terminal differentiation with heritable epigenetic modifications or plasticity in T cell responses. We generated genome-wide histone H3 lysine 4 (H3K4) and lysine 27 (H3K27) trimethylation maps in naīve, Th1, Th2, Th17, iTreg, and natural (n)Treg cells. We found that although modifications of signature cytokine genes (Ifng, Il4, and Il17) partially conform to the expectation of lineage commitment, critical transcription factors such as Tbx21 exhibit a broad spectrum of epigenetic states, consistent with our demonstration of T-bet and IFN-gamma induction in nTreg cells. Our data suggest an epigenetic mechanism underlying the specificity and plasticity of effector and regulatory T cells and also provide a framework for understanding complexity of CD4+ T helper cell differentiation.
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 19144320   Authors: Wei G,Wei L,Zhu J,Zang C,Hu-Li J,Yao Z,Cui K,Kanno Y,Roh TY,Watford WT,Schones DE,Peng W,Sun HW,Paul WE,O'Shea JJ,Zhao K.
Exact source GSE14308_1103_200_DN
Related gene sets (show 29 additional gene sets from the source publication)

(show 104 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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