Gene Set: GSE15215_CD2_POS_VS_NEG_PDC_UP

Standard name GSE15215_CD2_POS_VS_NEG_PDC_UP
Systematic name M3519
Brief description Genes up-regulated in comparison of CD2+ plasmacytoid dendritic cells (DC) versus CD2- cells.
Full description or abstract Plasmacytoid dendritic cells (pDCs) are key regulators of anti-viral immunity. They rapidly secrete IFN-alpha and cross-present viral antigens thereby launching adaptive immunity. Here we show that activated human pDCs inhibit replication of cancer cells, and kill them in a contact dependent fashion. Expression of CD2 distinguishes two pDC subsets with distinct phenotype and function. Both subsets secrete IFN-alpha and express Granzyme B and TRAIL. CD2high pDCs uniquely express lysozyme and can be found in tonsils and in tumors. Both subsets launch recall T cell response. However, CD2high pDCs secrete higher levels of IL12 p40, express higher levels of co-stimulatory molecule CD80 and are more efficient in triggering proliferation of na´ve allogeneic T cells. Thus, human blood pDCs are composed of subsets with specific phenotype and functions.
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 19454677   Authors: Matsui T,Connolly JE,Michnevitz M,Chaussabel D,Yu CI,Glaser C,Tindle S,Pypaert M,Freitas H,Piqueras B,Banchereau J,Palucka AK.
Exact source GSE15215_1537_200_UP
Related gene sets (show 1 additional gene sets from the source publication)

(show 179 gene sets from the same authors)
External links  
Filtered by similarity
Organism Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 196 genes
Gene families Categorize these 196 genes by gene family
Show members (show 200 members mapped to 196 genes)
Version history 7.3: Moved to ImmuneSigDB sub-collection.

See MSigDB license terms here. Please note that certain gene sets have special access terms.