Gene Set: GSE16522_ANTI_CD3CD28_STIM_VS_UNSTIM_MEMORY_CD8_TCELL_UP

Standard name GSE16522_ANTI_CD3CD28_STIM_VS_UNSTIM_MEMORY_CD8_TCELL_UP
Systematic name M3663
Brief description Genes up-regulated in comparison of stimulated memory CD8 T cells from pmel-1 mice versus unstimulated memory CD8 T cells from pmel-1 mice.
Full description or abstract Effector cells for adoptive immunotherapy can be generated by in vitro stimulation of na´ve or memory subsets of CD8+ T cells. While the characteristics of CD8+ T cell subsets are well defined, the heritable influence of those populations on their effector cell progeny is not well understood. We studied effector cells generated from na´ve or central memory CD8+ T cells and found that they retained distinct gene expression signatures and developmental programs. Effector cells derived from central memory cells tended to retain their CD62L+ phenotype, but also to acquire KLRG1, an indicator of cellular senescence. In contrast, the effector cell progeny of na´ve cells displayed reduced terminal differentiation, and, following infusion, they displayed greater expansion, cytokine production, and tumor destruction. These data indicate that effector cells retain a gene expression imprint conferred by their na´ve or central memory progenitors, and they suggest a strategy for enhancing cancer immunotherapy.
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 19805141   Authors: Hinrichs CS,Borman ZA,Cassard L,Gattinoni L,Spolski R,Yu Z,Sanchez-Perez L,Muranski P,Kern SJ,Logun C,Palmer DC,Ji Y,Reger RN,Leonard WJ,Danner RL,Rosenberg SA,Restifo NP.
Exact source GSE16522_1393_200_UP
Related gene sets (show 7 additional gene sets from the source publication)

(show 98 gene sets from the same authors)
External links  
Filtered by similarity
Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 200 genes
Gene families Categorize these 200 genes by gene family
Show members (show 200 members mapped to 200 genes)
Version history 7.3: Moved to ImmuneSigDB sub-collection.

See MSigDB license terms here. Please note that certain gene sets have special access terms.